Graduate Student, Department of Prosthodontics and Research Institute of Oral Science, College of Dentistry, Kangnung National University, Gangneung, Korea.
J Adv Prosthodont. 2009 Mar;1(1):10-8. doi: 10.4047/jap.2009.1.1.10. Epub 2009 Mar 31.
Despite an improved bone reactions of Mg-incorporated implants in the animals, little yet has been carried out by the experimental investigations in functional loading conditions.
This study investigated the clinical and histologic parameters of osseointegrated Mg-incorporated implants in early loading conditions.
A total of 36 solid screw implants (diameter 3.75 mm, length 10 mm) were placed in the mandibles of 6 beagle dogs. Test groups included 18 Mg-incorporated implants. Turned titanium implants served as control. Gold crowns were inserted 4 weeks after implant placement and the dogs were immediately put on a food diet. Implants were observed for 10 weeks after loading. Radiographic assessments and stability tests were performed at the time of fixture installation, 2(nd) stage surgery, 4 weeks after loading, and 10 weeks after loading. Histological observations and morphometrical measurements were also performed.
Of 36 implants, 33 displayed no discernible mobility, corresponding to successful clinical function. There was no statistically significant difference between test implants and controls in marginal bone levels (P = .46) and RFA values. The mean BIC% in the Mg-implants was 54.5 ± 8.4%. The mean BIC% in the turned implant was 45.3 ± 12.2%. These differences between the Mg-implant and control implant were statistically significant (P = .005).
The anodized, Mg-incorporated implant demonstrated significantly more bone-to-implant contact (BIC) in early loading conditions.
The results of this study in beagle dogs suggest the possibility of achieving predictable stability of early loaded free-standing dental implants with Mg-incorporated surface.
尽管镁掺入植入物在动物中的骨反应得到了改善，但在功能负载条件下，实验研究仍很少进行。
本研究调查了早期负载条件下骨整合镁掺入植入物的临床和组织学参数。
将 36 个实心螺钉植入物（直径 3.75mm，长度 10mm）放置在 6 只比格犬的下颌骨中。实验组包括 18 个镁掺入植入物。作为对照的是经旋转处理的钛植入物。植入物放置 4 周后插入金冠，狗立即开始正常进食。加载后 10 周观察植入物。在植入物安装时、第二期手术时、加载后 4 周和加载后 10 周进行放射评估和稳定性测试。还进行了组织学观察和形态测量。
在 36 个植入物中，有 33 个没有明显的活动度，表明临床功能成功。在边缘骨水平（P=.46）和 RFA 值方面，测试植入物和对照植入物之间没有统计学上的显著差异。镁植入物的平均 BIC%为 54.5±8.4%。经旋转处理的植入物的平均 BIC%为 45.3±12.2%。镁植入物和对照植入物之间的这些差异具有统计学意义（P=.005）。
在早期负载条件下，经过阳极氧化处理的镁掺入植入物显示出明显更多的骨与植入物接触（BIC）。
本研究在比格犬中的结果表明，具有镁掺入表面的早期负载独立牙植入物可能具有可预测的稳定性。
