Department of Surgical and Morphological Science, Dental School, University of Varese, 21100, Varese, Italy.
, Piazza Trento 4, 22015, Gravedona, Como, Italy.
Clin Oral Investig. 2017 Nov;21(8):2603-2611. doi: 10.1007/s00784-017-2061-y. Epub 2017 Feb 2.
The aim of this randomized, controlled histologic/histomorphometric study was to compare the early bone formation around immediately loaded implants with nanostructured calcium-incorporated (NCI) and machined (MA) surface, placed in the human posterior maxilla.
Fifteen fully edentulous patients (six males; nine females; mean age 57.9 ± 6.7 years) were selected for this study. Each patient was installed with two temporary transmucosal implants, with different surfaces: one NCI (test) and one MA (control) implant. All temporary implants were placed in the posterior maxilla, according to a split-mouth design, to help to support an interim complete maxillary denture. After 8 weeks, all temporary transmucosal implants were retrieved for histologic/histomorphometric evaluation. The bone-to-implant contact (BIC%) and the bone density (BD%) were calculated. The Wilcoxon matched-pairs signed-rank test was used to evaluate differences (BIC%, BD%) between the surfaces. The level of significance was set at 0.05.
Eight weeks after placement, 24 clinically stable implants (12 test, 12 control) were subjected to histologic/histomorphometric evaluation. In the MA implants, the histomorphometric evaluation revealed a mean BIC(±SD)% and BD(±SD)% of 21.2(±4.9)% and 29.8(±7.8)%, respectively. In the NCI implants, the histomorphometric analysis revealed a mean BIC(±SD)% and BD(±SD)% of 39.7(±8.7)% and 34.6(±7.2)%, respectively. A statistically significant difference was found between the two surfaces with regard to BIC% (p < 0.001), while no significant difference was found with regard to BD% (p = 0.09).
The NCI surface seems to increase the peri-implant endosseous healing properties in the native bone of the posterior maxilla, under immediate loading conditions, when compared with the MA surface.
Under immediate loading conditions in the human posterior maxilla, the nanostructured calcium-incorporated surface has led to better histologic and histomorphometric results than the machined surface; therefore, the clinical use of implants with nanostructured calcium-incorporated surface may be beneficial in the posterior maxilla, under immediate loading protocol.
本随机对照组织学/组织形态计量学研究的目的是比较即刻负重植入物周围早期骨形成，比较纳米结构钙掺入（NCI）和机械加工（MA）表面，放置在人类上颌后部。
选择了 15 名完全无牙患者（6 名男性；9 名女性；平均年龄 57.9±6.7 岁）进行这项研究。每位患者均植入 2 个临时黏膜下植入物，具有不同的表面：一个 NCI（测试）和一个 MA（对照）植入物。根据分口设计，所有临时植入物均放置在上颌后部，以帮助支持临时上颌全口义齿。8 周后，所有临时黏膜下植入物均取出进行组织学/组织形态计量学评估。计算骨-种植体接触（BIC%）和骨密度（BD%）。使用 Wilcoxon 配对符号秩检验评估表面之间的差异（BIC%，BD%）。显著性水平设为 0.05。
放置后 8 周，24 个临床稳定的植入物（12 个测试，12 个对照）进行了组织学/组织形态计量学评估。在 MA 植入物中，组织形态计量评估显示平均 BIC（±SD）%和 BD（±SD）%分别为 21.2（±4.9）%和 29.8（±7.8）%。在 NCI 植入物中，组织形态分析显示平均 BIC（±SD）%和 BD（±SD）%分别为 39.7（±8.7）%和 34.6（±7.2）%。两种表面的 BIC%差异具有统计学意义（p<0.001），而 BD%差异无统计学意义（p=0.09）。
与 MA 表面相比，在即刻负重条件下，NCI 表面似乎增加了上颌后部天然骨的种植体周围骨内愈合特性。
在人类上颌后部即刻负重条件下，纳米结构钙掺入表面的组织学和组织形态计量结果优于机械加工表面；因此，在即刻加载方案下，使用纳米结构钙掺入表面的植入物可能对上颌后部有益。
