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肺的多形性癌伴高血清β-人绒毛膜促性腺激素水平和男性乳房发育。

Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia.

机构信息

Department of Medical Oncology, Istanbul Bilim University School of Medicine, Istanbul, Turkey.

出版信息

J Korean Med Sci. 2010 Dec;25(12):1805-8. doi: 10.3346/jkms.2010.25.12.1805. Epub 2010 Nov 24.

DOI:10.3346/jkms.2010.25.12.1805
PMID:21165299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2995238/
Abstract

Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.

摘要

虽然男性乳房发育症是一种在非小细胞肺癌患者中明确的副肿瘤综合征，但与多形性癌的关联尚未报道。一名 50 岁男性出现双侧男性乳房发育症和血清β-人绒毛膜促性腺激素（βhCG）水平升高。胸部 CT 显示右中叶有一个肿块。进行了右中叶切除术和纵隔淋巴结清扫术。手术后βhCG 水平迅速下降。组织学检查显示多形性癌，βhCG 免疫染色阳性。术后第 4 个月，血清βhCG 水平开始逐渐升高。计算机断层扫描发现复发并开始化疗。第二次化疗周期后，βhCG 水平再次急剧下降，CT 显示肿块缩小。患者 6 个月后因脑转移死亡。βhCG 表达可能与侵袭性临床病程和复发风险增加有关，βhCG 水平也可用于评估多形性癌患者的治疗反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/40249c1ee71a/jkms-25-1805-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/396548cdc82d/jkms-25-1805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/fbb79f853392/jkms-25-1805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/40249c1ee71a/jkms-25-1805-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/396548cdc82d/jkms-25-1805-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/fbb79f853392/jkms-25-1805-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7336/2995238/40249c1ee71a/jkms-25-1805-g003.jpg

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