Kawaguchi Yoshiharu, Seki Shoji, Yasuda Taketoshi, Nakamura Yumiko, Nakano Masato, Kimura Tomoatsu
Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan.
Asian Spine J. 2010 Dec;4(2):136-40. doi: 10.4184/asj.2010.4.2.136. Epub 2010 Nov 24.
Postoperative meningitis after spinal surgery is a rare complication that can result in a life-threatening condition. Linezolid (LZD) is an oxazolidinone which has been approved in Japan for infections caused by methicillin-resistant Staphylococcus aureus. The authors encountered a case of postoperative meningitis with cerebrospinal fluid leakage (liquorrhoea) that occurred after resection of a cervical cord tumor. The infection was caused by methicillin-resistant Staphylococcus epidermidis(MRSE). Debridement and suture of the dura matter was carried out. LZD was given intravenously. The infection was cured without any sequelae. Based on this result, we concluded that LZD might be considered as one of the first choices for the treatment of postsurgical meningitis caused by MRSE.
脊柱手术后的术后脑膜炎是一种罕见的并发症,可导致危及生命的状况。利奈唑胺(LZD)是一种恶唑烷酮类药物,在日本已被批准用于治疗耐甲氧西林金黄色葡萄球菌引起的感染。作者遇到一例颈髓肿瘤切除术后发生的伴有脑脊液漏(脑脊液外漏)的术后脑膜炎病例。感染由耐甲氧西林表皮葡萄球菌(MRSE)引起。进行了硬脑膜清创和缝合。静脉给予利奈唑胺。感染治愈且无任何后遗症。基于此结果,我们得出结论,利奈唑胺可被视为治疗由MRSE引起的术后脑膜炎的首选药物之一。