Ragino Yu I, Chernjavski A M, Polonskaja Ya V, Tchimbal S Yu, Redjkin D A, Semaeva E V, Kashtanova E V, Voevoda M I
E. N. Meshalkin Research Institute of Circulatory Pathology, Federal Agency for High-Technological Medical Care, Novosibirsk, Russia.
Bull Exp Biol Med. 2010 Oct;149(5):587-90. doi: 10.1007/s10517-010-0999-8.
In male patients with coronary atherosclerosis without acute coronary syndrome, the levels of inflammatory-destructive biomarkers of atherosclerotic plaque instability depended on the severity and dissemination of coronary atherosclerosis. The highest levels of C-reactive protein and matrix metalloproteinase 3 were found in men with atherosclerotic involvement of all three main coronary arteries, primarily their middle and distal segments, and in men with predominance of low-grade stenoses (<50%) of coronary arteries in areas of atherosclerotic plaques.
在无急性冠状动脉综合征的男性冠状动脉粥样硬化患者中，动脉粥样硬化斑块不稳定的炎症破坏性生物标志物水平取决于冠状动脉粥样硬化的严重程度和范围。在所有三支主要冠状动脉（主要是其中段和远端）均有动脉粥样硬化累及的男性患者中，以及在动脉粥样硬化斑块区域以冠状动脉低度狭窄（<50%）为主的男性患者中，发现C反应蛋白和基质金属蛋白酶3水平最高。
