Genetics and Population Health Division, Queensland Institute of Medical Research, Herston, 4006, Brisbane, Australia.
Breast Cancer Res Treat. 2011 Feb;126(1):235-9. doi: 10.1007/s10549-010-1292-2. Epub 2010 Dec 17.
ABCC11 is an ATP-binding cassette transporter responsible for the transport of a diverse range of lipophilic compounds. A single nucleotide polymorphism (SNP) encoding an amino acid change has recently been shown to determine whether cerumen (earwax) is wet or dry. We hypothesised that this ABCC11 SNP may be associated with breast cancer risk because an association has been reported between wet earwax and increased risk of breast cancer. We therefore analysed the frequency of the functional SNP in 1342 cases and 2256 controls from two breast cancer studies of Caucasian women but found no evidence for an association with breast cancer risk.
ABCC11 是一种 ATP 结合盒转运蛋白，负责运输多种脂溶性化合物。最近的研究表明，一个编码氨基酸变化的单核苷酸多态性（SNP）决定了耳垢（耵聍）是湿的还是干的。我们假设这个 ABCC11 SNP 可能与乳腺癌风险有关，因为有报道称湿耳垢与乳腺癌风险增加有关。因此，我们分析了来自两个白人女性乳腺癌研究的 1342 例病例和 2256 例对照中该功能 SNP 的频率，但没有发现与乳腺癌风险相关的证据。
