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[纤维化间质性肺炎的影像学]

[Imaging of fibrosing interstitial pneumonias].

作者信息

Grenier Philippe, Brauner Michel

机构信息

Radiologie, Hôpital Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75651 Paris cedex 13.

出版信息

Bull Acad Natl Med. 2010 Feb;194(2):353-64; discussion 364-5.

Abstract

The term fibrosing interstitial pneumonia covers several distinct entities, including usual interstitial pneumonia, non specific interstitial pneumonia acute interstitial pneumonia, desquamative interstitial pneumonia, and lymphoid interstitial pneumonia. Because of its very poor prognosis and different management, usual interstitial pneumonia, and particularly idiopathic forms (idiopathic pulmonary fibrosis), must be distinguished from other forms of interstitial pneumonia. The diagnosis of idiopathic pulmonary fibrosis is based on the CT or pathologic criteria of usual interstitial pneumonia, in the absence of asbestosis, chronic hypersensitive pneumonitis, and collagen vascular disease. In more than 50% of cases, idiopathic pulmonary fibrosis may be confidently diagnosed on the basis of CT findings, showing reticular opacities and honeycombing with a predominantly basal and subpleural distribution, without nodules, extensive consolidation or ground-glass opacities. Surgical biopsy may be necessary when these features are absent, given the overlap of CT findings between the different forms of interstitial pneumonia. In such cases, specific diagnosis of interstitial lung disease is based on a combination of clinical, radiological and histopathological findings.

摘要

纤维化间质性肺炎这一术语涵盖了几种不同的疾病实体,包括寻常型间质性肺炎、非特异性间质性肺炎、急性间质性肺炎、脱屑性间质性肺炎和淋巴细胞间质性肺炎。由于其预后极差且治疗方法不同,寻常型间质性肺炎,尤其是特发性形式(特发性肺纤维化),必须与其他形式的间质性肺炎相区分。特发性肺纤维化的诊断基于寻常型间质性肺炎的CT或病理标准,且不存在石棉沉着病、慢性过敏性肺炎和胶原血管病。在超过50%的病例中,根据CT表现可确诊特发性肺纤维化,表现为网状阴影和蜂窝状改变,主要分布在肺底部和胸膜下,无结节、广泛实变或磨玻璃影。当缺乏这些特征时,鉴于不同形式间质性肺炎的CT表现存在重叠,手术活检可能是必要的。在这种情况下,间质性肺疾病的特异性诊断基于临床、放射学和组织病理学检查结果的综合判断。

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