Tunc Turan, Karaoglu Abdulbaki, Cayci Tuncer, Demirkaya Erkan, Kul Mustafa, Yaman Halil, Karadeniz Sinan, Gungor Tayfun, Alpay Faruk
Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
Pediatr Int. 2010 Dec;52(6):872-5. doi: 10.1111/j.1442-200X.2010.03213.x.
The perinatal morbidity risk is higher in operative deliveries than normal vaginal deliveries. 'Tau protein' is a cytoskeletal component that is predominantly expressed in axons of neurons. The aim of this study was to investigate whether delivery type, particularly the forceps application, had any effect on cord blood tau levels.
Ninety babies born in the Division of Maternal-Fetal Medicine of Ankara Etlik Maternity and Women's Health Teaching Hospital, Ankara, Turkey were involved in the study. The babies were divided into three groups according to delivery type: Group 1: normal vaginal delivery (NVD); Group 2: caesarean section; Group 3: forceps application. Cord blood samples were drawn from umbilical veins of the babies soon after the birth.
The cord blood tau protein levels in the caesarean section group (79 pg/mL [45-223]) were found to be significantly lower than those of NVD (135 pg/mL [44-627]) and forceps (175 pg/mL [17-418]) groups (P = 0.001 and P < 0.001, respectively).
We have shown that forceps applications uncomplicated with perinatal asphyxia did not affect the cord blood tau protein level significantly. Tau levels in caesarean section group were significantly lower than the other two groups. Caesarean section in this manner might be considered especially in conditions of risk of perinatal asphyxia to avoid hypoxia.
手术分娩的围产期发病风险高于正常阴道分娩。“tau蛋白”是一种细胞骨架成分，主要在神经元轴突中表达。本研究的目的是调查分娩方式，特别是产钳助产，是否对脐血tau水平有任何影响。
土耳其安卡拉埃特利克妇产与妇女健康教学医院母胎医学科出生的90名婴儿参与了该研究。根据分娩方式将婴儿分为三组：第1组：正常阴道分娩（NVD）；第2组：剖宫产；第3组：产钳助产。出生后不久从婴儿的脐静脉采集脐血样本。
发现剖宫产组的脐血tau蛋白水平（79 pg/mL [45 - 223]）显著低于正常阴道分娩组（135 pg/mL [44 - 627]）和产钳助产组（175 pg/mL [17 - 418]）（分别为P = 0.001和P < 0.001）。
我们已经表明，无围产期窒息并发症的产钳助产对脐血tau蛋白水平没有显著影响。剖宫产组的tau水平显著低于其他两组。在存在围产期窒息风险的情况下，尤其可以考虑以这种方式进行剖宫产以避免缺氧。
