[γ射线照射期间大鼠肝脏微粒体中UDP-葡萄糖醛酸基转移酶、谷胱甘肽-S-转移酶的变化及脂质过氧化作用以及α-生育酚的保护作用]
[Changes in UDP-glucuronosyl-, glutathione-S-transferase and lipid peroxidation in rat liver microsomes during gamma-irradiation and protective effect of alpha-tocopherol].
作者信息
Legon'kova L F, Abakumov G Z, Bushma M I, Lukienko P I
出版信息
Vopr Med Khim. 1990 May-Jun;36(3):26-8.
PMID:2116695
Abstract
Stimulation of lipid peroxidation, accompanied by a decrease in activity of UDP-glucuronyl- and glutathione-S-transferases, was observed in rat liver microsomes within one day after gamma-irradiation. Maximal alteration of the patterns studied was detected within 5 days. Preadministration of alpha-tocopherol, within 14 days at a dose of 200 mg/kg of body mass, prevented distinctly the impairing effect of irradiation.
摘要
在γ射线照射后的一天内，在大鼠肝脏微粒体中观察到脂质过氧化的刺激，同时伴有UDP-葡萄糖醛酸基转移酶和谷胱甘肽-S-转移酶活性的降低。在5天内检测到所研究模式的最大变化。在14天内以200mg/kg体重的剂量预先给予α-生育酚，明显预防了辐射的损害作用。
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