Department of Clinical Laboratory Technology, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, China.
Autoimmun Rev. 2011 Apr;10(6):331-5. doi: 10.1016/j.autrev.2010.12.002. Epub 2010 Dec 15.
Cancer sera contain antibodies that react with a unique group of autologous cellular antigens called tumor-associated antigens (TAAs), and therefore these autoantibodies can be considered as reporters from the immune system, to identify authentic TAAs involved in the malignant transformation. Once a TAA is identified, different approaches would be used to comprehensively characterize and validate the identified TAA/anti-TAA systems that are potential biomarkers in cancer immunodiagnosis. In this manner, several novel TAAs such as p62 and p90 have been identified in our previous studies. p62, a member of IGF-II mRNA binding proteins (IMPs), is an oncofetal protein absent in adult tissues, the presence of anti-p62 autoantibodies relates to abnormal expression of p62 in tumor cells. p90 was recently characterized as an inhibitor of the tumor suppressor PP2A (protein phosphatase 2A), and an autoantibody to p90 appears in high frequency in prostate cancer. The present review will focus on the recent advances in studies mainly associated with these two novel TAAs as biomarkers in cancer immunodiagnosis.
癌症血清中含有与称为肿瘤相关抗原 (TAA) 的一组独特的自体细胞抗原反应的抗体,因此这些自身抗体可以被视为免疫系统的报告者,以识别参与恶性转化的真实 TAA。一旦鉴定出 TAA,就会采用不同的方法来全面表征和验证鉴定出的 TAA/抗 TAA 系统,这些系统是癌症免疫诊断中的潜在生物标志物。通过这种方式,在我们之前的研究中已经鉴定出了几种新型 TAA,如 p62 和 p90。p62 是胰岛素样生长因子 II mRNA 结合蛋白 (IGF-II mRNA binding proteins,IMPs) 的成员,是一种在成人组织中不存在的癌胚蛋白,抗 p62 自身抗体的存在与肿瘤细胞中 p62 的异常表达有关。p90 最近被表征为肿瘤抑制因子 PP2A(蛋白磷酸酶 2A)的抑制剂,并且在前列腺癌中 p90 自身抗体的出现频率很高。本综述将重点介绍与这两种新型 TAA 作为癌症免疫诊断生物标志物相关的最新研究进展。