The Vivian L Smith Department of Neurosurgery, The University of Texas Medical School at Houston, Houston, TX 77030, United States.
Epilepsy Res. 2011 Feb;93(2-3):197-203. doi: 10.1016/j.eplepsyres.2010.11.009. Epub 2010 Dec 18.
Mesial temporal lobe epilepsy (MTLE) is hypothesized to involve derangement of long-range limbic connectivity, but in vivo evidence is lacking. We used diffusion tractography to investigate the relationship between hippocampal atrophy and connectivity in MTLE patients with hippocampal sclerosis (HS). Atrophy was correlated with relatively decreased connectivity density but increased connectivity strength, suggesting that HS is accompanied by relatively sparse but strong connections as measured by diffusion anisotropy.
内侧颞叶癫痫（MTLE）被假设涉及长程边缘连接的紊乱，但缺乏体内证据。我们使用弥散张量成像来研究伴有海马硬化（HS）的 MTLE 患者的海马萎缩与连接之间的关系。萎缩与相对较低的连接密度相关，但与较高的连接强度相关，这表明 HS 伴随着相对稀疏但较强的连接，如弥散各向异性所测量的那样。
