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[口咽吞咽困难作为皮肌炎合并结肠癌的首发表现]

[Oropharyngeal dysphagia as a first manifestation of dermatomyositis associated with colon cancer].

作者信息

Espinoza-Cobos J C, Pérez-Figueroa J, Zúñiga-Ahuet G, Dorantes M A, Grube-Pagola P, Ruíz-Juárez I, Remes-Troche J M

机构信息

Universidad Autónoma de Ciudad Juárez, Chihuahua, México, D. F.

出版信息

Rev Gastroenterol Mex. 2010 Oct-Dec;75(4):522-7.

Abstract

Dermatomyositis (DM) is an idiopathic inflammatory myopathy associated with characteristic skin manifestations. In 15-20% of patients present with dysphagia, it is associated with nutritional deficiency, predisposition to aspiration pneumonia, decreased quality of life and a poor prognosis. There is a well-recognized association between DM and malignancies, including ovarian, breast, lung, and colon cancer. We report a case of a male patient aged 85 with DM associated with colon adenocarcinoma; progressive dysphagia was the first manifestation, and subsequently proximal muscle weakness and typical skin lesions were present. Given the clinical suspicion of DM as a paraneoplastic syndrome, tumor markers were order and a high carcinoembryonic antigen was found. A colonoscopy study and histopathologic examination revealed the presence of adenocarcinoma of the colon.

摘要

皮肌炎(DM)是一种特发性炎性肌病,伴有特征性皮肤表现。15%至20%的患者会出现吞咽困难,这与营养缺乏、易患吸入性肺炎、生活质量下降及预后不良有关。DM与恶性肿瘤之间存在公认的关联,包括卵巢癌、乳腺癌、肺癌和结肠癌。我们报告一例85岁男性患者,患有与结肠腺癌相关的DM;进行性吞咽困难是首发表现,随后出现近端肌无力和典型皮肤病变。鉴于临床怀疑DM为副肿瘤综合征,于是检测了肿瘤标志物,发现癌胚抗原水平升高。结肠镜检查和组织病理学检查显示存在结肠腺癌。

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