agr 基因座对金黄色葡萄球菌菌落在传播中的要求。
Requirement of the agr locus for colony spreading of Staphylococcus aureus.
机构信息
Department of Medical Microbiology, University Medical Center Groningen, RB Groningen, Netherlands.
出版信息
J Bacteriol. 2011 Mar;193(5):1267-72. doi: 10.1128/JB.01276-10. Epub 2010 Dec 17.
Abstract
The important human pathogen Staphylococcus aureus is known to spread on soft agar plates. Here, we show that colony spreading of S. aureus involves the agr quorum-sensing system. This finding can be related to the agr-dependent expression of biosurfactants, such as phenol-soluble modulins, suggesting a connection between spreading motility and virulence.
摘要
重要的人类病原体金黄色葡萄球菌已知会在软琼脂平板上传播。在这里，我们表明金黄色葡萄球菌的菌落扩散涉及 agr 群体感应系统。这一发现可以与 agr 依赖性生物表面活性剂（如酚可溶性调节素）的表达相关联，表明扩散运动性和毒力之间存在联系。
相似文献
1
Requirement of the agr locus for colony spreading of Staphylococcus aureus.agr 基因座对金黄色葡萄球菌菌落在传播中的要求。
J Bacteriol. 2011 Mar;193(5):1267-72. doi: 10.1128/JB.01276-10. Epub 2010 Dec 17.
2
Sugar-responsive gene expression and the agr system are required for colony spreading in Staphylococcus aureus.糖应答基因表达和 Agr 系统是金黄色葡萄球菌菌落扩散所必需的。
Microb Pathog. 2011 Sep;51(3):178-85. doi: 10.1016/j.micpath.2011.04.003. Epub 2011 Apr 14.
3
Allele-dependent differences in quorum-sensing dynamics result in variant expression of virulence genes in Staphylococcus aureus.群体感应动力学中的等位基因依赖性差异导致金黄色葡萄球菌中毒力基因的表达发生变异。
J Bacteriol. 2012 Jun;194(11):2854-64. doi: 10.1128/JB.06685-11. Epub 2012 Mar 30.
4
Oxidative stress drives the selection of quorum sensing mutants in the population.氧化应激驱动群体感应突变体在种群中的选择。
Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19145-19154. doi: 10.1073/pnas.1902752116. Epub 2019 Sep 5.
5
Inactivation of traP has no effect on the agr quorum-sensing system or virulence of Staphylococcus aureus.traP 的失活对金黄色葡萄球菌的 agr 群体感应系统或毒力没有影响。
Infect Immun. 2007 Sep;75(9):4519-27. doi: 10.1128/IAI.00491-07. Epub 2007 Jun 4.
6
Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325.腐生葡萄球菌和葡萄球菌 aureus NCTC8325 调节 clfB 表达主要通过调控纤维蛋白原结合能力。
Med Microbiol Immunol. 2012 Feb;201(1):81-92. doi: 10.1007/s00430-011-0208-z. Epub 2011 Jun 24.
7
Finding of Agr Phase Variants in Staphylococcus aureus.金黄色葡萄球菌 Agr 相变体的发现。
mBio. 2019 Aug 6;10(4):e00796-19. doi: 10.1128/mBio.00796-19.
8
Mucin-induced surface dispersal of and via quorum-sensing dependent and independent mechanisms.黏液诱导通过群体感应依赖和独立机制的 和 的表面分散。
mBio. 2024 Aug 14;15(8):e0156224. doi: 10.1128/mbio.01562-24. Epub 2024 Jul 2.
9
Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus.抗生素介导的群体感应阴性金黄色葡萄球菌选择。
mBio. 2013 Jan 2;3(6):e00459-12. doi: 10.1128/mBio.00459-12.
10
The staphylococcus-specific gene rsr represses agr and virulence in Staphylococcus aureus.金黄色葡萄球菌特异性基因 rsr 抑制 agr 和金黄色葡萄球菌的毒力。
Infect Immun. 2010 Oct;78(10):4384-91. doi: 10.1128/IAI.00401-10. Epub 2010 Aug 9.
引用本文的文献
1
Rhizobial, passenger nodule endophytes and phyllosphere bacteria in combination with acyl homoserine lactones enhances the growth and yield of groundnut.根瘤菌、寄生性根瘤内生菌和叶际细菌与酰基高丝氨酸内酯结合可提高花生的生长和产量。
Biotechnol Rep (Amst). 2025 Apr 4;46:e00893. doi: 10.1016/j.btre.2025.e00893. eCollection 2025 Jun.
2
Bactericidal and anti-quorum sensing activity of repurposing drug Visomitin against .重新利用药物 Visomitin 对. 的杀菌和抗群体感应活性。
Virulence. 2024 Dec;15(1):2415952. doi: 10.1080/21505594.2024.2415952. Epub 2024 Oct 19.
3
Interspecies surfactants serve as public goods enabling surface motility in .种间表面活性剂充当公共物品，使 表面运动成为可能。
J Bacteriol. 2024 Oct 24;206(10):e0028124. doi: 10.1128/jb.00281-24. Epub 2024 Sep 5.
4
Mucin-induced surface dispersal of and via quorum-sensing dependent and independent mechanisms.黏液诱导通过群体感应依赖和独立机制的 和 的表面分散。
mBio. 2024 Aug 14;15(8):e0156224. doi: 10.1128/mbio.01562-24. Epub 2024 Jul 2.
5
Interspecies surfactants serve as public goods enabling surface motility in .种间表面活性剂作为公共物品，使（某环境中的）表面运动成为可能。 （注：原句中“in.”后面内容缺失）
bioRxiv. 2024 Apr 22:2024.01.03.573969. doi: 10.1101/2024.01.03.573969.
6
The great divide: rhamnolipids mediate separation between and .巨大的鸿沟：鼠李糖脂介导 和 之间的分离。
Front Cell Infect Microbiol. 2023 Sep 15;13:1245874. doi: 10.3389/fcimb.2023.1245874. eCollection 2023.
7
Hitchhiking motility of involves the interaction between its wall teichoic acids and lipopolysaccharide of .[细菌名称]的搭便车运动性涉及到其壁磷壁酸与[细菌名称]的脂多糖之间的相互作用。 （注：原文中两个“of ”后面的内容缺失，这里用“[细菌名称]”表示需补充的细菌名称）
Front Microbiol. 2023 Jan 5;13:1068251. doi: 10.3389/fmicb.2022.1068251. eCollection 2022.
8
Effect of Cobalt-Chromium-Molybdenum Implant Surface Modifications on Biofilm Development of and .钴铬钼植入物表面改性对 和 生物膜形成的影响。
Front Cell Infect Microbiol. 2022 Mar 1;12:837124. doi: 10.3389/fcimb.2022.837124. eCollection 2022.
9
Accessory Gene Regulator () Allelic Variants in Cognate Strain Display Similar Phenotypes.同源菌株中辅助基因调控因子（）等位基因变体表现出相似的表型。
Front Microbiol. 2022 Feb 25;13:700894. doi: 10.3389/fmicb.2022.700894. eCollection 2022.
10
Varied Contribution of Phospholipid Shedding From Membrane to Daptomycin Tolerance in .膜磷脂脱落对达托霉素耐受性的不同贡献 。 （原文句子不完整，翻译只能做到此程度）
Front Mol Biosci. 2021 Jun 11;8:679949. doi: 10.3389/fmolb.2021.679949. eCollection 2021.
本文引用的文献
1
Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates.金黄色葡萄球菌 8325 中全局调控因子的修复与其他临床分离株的比较分析。
Infect Immun. 2010 Jun;78(6):2877-89. doi: 10.1128/IAI.00088-10. Epub 2010 Mar 8.
2
Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation.蛋白质组学揭示了由于基因组可塑性和变异基因调控，金黄色葡萄球菌外蛋白质组存在极端异质性。
Proteomics. 2010 Apr;10(8):1634-44. doi: 10.1002/pmic.200900313.
3
Recombination between ccrC genes in a type V (5C2&5) staphylococcal cassette chromosome mec (SCCmec) of Staphylococcus aureus ST398 leads to conversion from methicillin resistance to methicillin susceptibility in vivo.金黄色葡萄球菌 ST398 型 V 组（5C2&5）葡萄球菌盒式染色体 mec（SCCmec）中 ccrC 基因的重组导致体内由耐甲氧西林转换为甲氧西林敏感。
Antimicrob Agents Chemother. 2010 Feb;54(2):783-91. doi: 10.1128/AAC.00696-09. Epub 2009 Dec 7.
4
Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements.葡萄球菌盒式染色体mec（SCCmec）分类：报告新型SCCmec元件的指南。
Antimicrob Agents Chemother. 2009 Dec;53(12):4961-7. doi: 10.1128/AAC.00579-09. Epub 2009 Aug 31.
5
Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA.移动遗传元件编码的细胞溶素将耐甲氧西林金黄色葡萄球菌的毒力与耐甲氧西林性联系起来。
PLoS Pathog. 2009 Jul;5(7):e1000533. doi: 10.1371/journal.ppat.1000533. Epub 2009 Jul 31.
6
Relevant role of fibronectin-binding proteins in Staphylococcus aureus biofilm-associated foreign-body infections.纤连蛋白结合蛋白在金黄色葡萄球菌生物膜相关异物感染中的相关作用
Infect Immun. 2009 Sep;77(9):3978-91. doi: 10.1128/IAI.00616-09. Epub 2009 Jul 6.
7
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus.社区获得性耐甲氧西林金黄色葡萄球菌流行株毒力的演变
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5883-8. doi: 10.1073/pnas.0900743106. Epub 2009 Mar 17.
8
CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression.金黄色葡萄球菌中的CodY：代谢与毒力基因表达之间的调控联系。
J Bacteriol. 2009 May;191(9):2953-63. doi: 10.1128/JB.01492-08. Epub 2009 Feb 27.
9
A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus.葡萄球菌盒式染色体 mec 区域中的一个新基因 fudoh 可抑制金黄色葡萄球菌的菌落扩散能力和毒力。
PLoS One. 2008;3(12):e3921. doi: 10.1371/journal.pone.0003921. Epub 2008 Dec 11.
10
Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains.定植金黄色葡萄球菌菌株中agr功能障碍的患病率。
J Infect Dis. 2008 Oct 15;198(8):1171-4. doi: 10.1086/592051.
Zotero 插件