Valmier J, Touchon J, Blayac J P, Baldy-Moulinier M
Department of Clinical Neurophysiology, INSERM U.249, CNRS LP 8402, University Hospital, Montpellier, France.
Epilepsy Res. 1990 Apr;5(3):229-34. doi: 10.1016/0920-1211(90)90043-u.
The effect of the initiation of carbamazepine (CBZ) treatment on regional cerebral blood flow (rCBF) was studied using the intravenous Xenon technique in a group of epileptic patients suffering from complex partial seizures. A slight increase in mean rCBF (10.8 +/- 8.8%, P less than 0.01) was observed in 12 patients after the first month of CBZ treatment, while no rCBF change was found after 6 months of CBZ treatment. Regional analysis showed that the rCBF increase following 1 month of CBZ treatment involved all cortical regions with the exception of the right occipital region, irrespective of the initial value. Repeated rCBF measurements performed in normal volunteers (N = 6) and in epileptic patients (N = 10), chronically treated and not subjected to therapeutic modification, showed no significant change. The initial effect of CBZ on CBF found at the onset of the treatment but not after 4-6 months may be related to the improvement in epilepsy and in cerebral function (as suggested by cognitive findings).
采用静脉注射氙技术，对一组患有复杂部分性发作的癫痫患者进行研究，以探讨卡马西平（CBZ）治疗起始对局部脑血流量（rCBF）的影响。在CBZ治疗的第一个月后，12例患者的平均rCBF略有增加（10.8±8.8%，P<0.01），而在CBZ治疗6个月后未发现rCBF变化。区域分析表明，CBZ治疗1个月后rCBF增加涉及所有皮质区域，但右侧枕叶区域除外，与初始值无关。在正常志愿者（N = 6）和长期接受治疗且未进行治疗调整的癫痫患者（N = 10）中进行的重复rCBF测量显示无显著变化。治疗开始时发现CBZ对CBF有初始效应，但4-6个月后未发现，这可能与癫痫和脑功能的改善有关（如认知结果所示）。
