Department of Pathology, University of California-San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA.
Adv Anat Pathol. 2011 Jan;18(1):90-7. doi: 10.1097/PAP.0b013e3182026da6.
Papillary thyroid carcinoma is the most common type of thyroid malignancy. The diagnostic features of these tumors include characteristic nuclear cytology. However, many variants have been reported with different morphology and molecular profiles. Although the vast majority of papillary thyroid carcinomas have an excellent prognosis, some variants of papillary thyroid carcinoma can have a more aggressive course. With this increased attention to papillary thyroid carcinoma variants has come the need to sort out which variants are clinically important and should be recognized by practicing pathologists. The main objectives of this review article are to (1) summarize the gross and histopathologic features of papillary thyroid carcinoma; (2) provide an overview of the subtypes of papillary thyroid carcinoma and their prognosis; (3) discuss established and emerging data on the immunohistochemical findings that are helpful in differential diagnosis; and (4) summarize molecular findings and pathogenesis of these lesions.
甲状腺乳头状癌是最常见的甲状腺恶性肿瘤。这些肿瘤的诊断特征包括特征性的核细胞学。然而，已经报道了许多具有不同形态和分子特征的变体。尽管绝大多数甲状腺乳头状癌预后良好，但一些甲状腺乳头状癌变体可能具有更具侵袭性的病程。随着对甲状腺乳头状癌变体的关注增加，需要理清哪些变体具有临床重要性，并且应该被临床病理学家所识别。本文综述的主要目的是：(1)总结甲状腺乳头状癌的大体和组织病理学特征；(2)概述甲状腺乳头状癌的亚型及其预后；(3)讨论有助于鉴别诊断的免疫组织化学发现的现有和新数据；(4)总结这些病变的分子发现和发病机制。
