Department of Surgical Pathology, SA Pathology at Flinders Medical Centre, Bedford Park, South Australia.
Adv Anat Pathol. 2011 Jan;18(1):98-100. doi: 10.1097/PAP.0b013e3182026d8f.
Pancreatic lymphoepithelial cysts are more common in men, can occur anywhere in the pancreas, are sharply demarcated from surrounding tissues, and range in size from 1.2 to 17 cm. Patients are usually middle aged, presenting symptoms include abdominal pain, nausea, vomiting, and diarrhea, although many tumors are asymptomatic and are discovered incidentally on organ imaging or at autopsy. An elevated serum carbohydrate-associated antigen 19-9 may wrongly suggest a mucinous neoplasm. The diagnosis can be made preoperatively with a combination of organ imaging, fine needle aspiration biopsy, or ultrasound-guided Trucut biopsies. Cysts can be unilocular, bilocular, or multilocular, have walls up to 0.6 cm thick which are lined by squamous epithelium, occasional columnar mucinous cells, and small foci of sebaceous cells. The epithelium is surrounded by a dense rim of lymphoid tissue with scattered lymphoid follicles. Invaginations of the epithelium into the lymphoid tissue, reminiscent of a Warthin tumor, are occasionally observed. The pathogenesis is unknown. Pancreatic lymphoepithelial cysts are cured by conservative resection but if they are asymptomatic and are diagnosed before surgery, no treatment is necessary.
胰腺淋巴上皮囊肿多见于男性，可发生于胰腺的任何部位，与周围组织界限清楚，大小为 1.2 至 17 厘米。患者通常为中年人，表现为腹痛、恶心、呕吐和腹泻等症状，但许多肿瘤无症状，在器官成像或尸检时偶然发现。血清碳水化合物相关抗原 19-9 升高可能错误提示黏液性肿瘤。术前可通过器官成像、细针抽吸活检或超声引导 Trucut 活检进行诊断。囊肿可为单房性、双房性或多房性，囊壁最厚可达 0.6 厘米，由鳞状上皮、偶尔的柱状黏液细胞和少量的皮脂腺细胞组成。上皮被致密的淋巴组织环绕，伴有散在的淋巴滤泡。上皮向淋巴组织内陷，类似于沃辛瘤，偶尔可见。发病机制不明。胰腺淋巴上皮囊肿通过保守性切除即可治愈，但如果无症状且在术前诊断，无需治疗。
