鸟氨酸脱羧酶mRNA的积累伴随着人和小鼠单核细胞/巨噬细胞的激活。
Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/macrophages.
作者信息
Messina L, Arcidiacono A, Spampinato G, Malaguarnera L, Berton G, Kaczmarek L, Messina A
机构信息
Institute of General Pathology, University of Catania, Italy.
出版信息
FEBS Lett. 1990 Jul 30;268(1):32-4. doi: 10.1016/0014-5793(90)80965-l.
Accumulation of ornithine decarboxylase (ODC) mRNA was investigated in human monocytes and mouse peritoneal macrophages. Treatment of both populations of mononuclear phagocytes with bacterial lipopolysaccharide induced a marked and rapid increase in the accumulation of the ODC gene transcript. A similar phenomenon, albeit less pronounced, was also observed following treatment of human monocytes with human recombinant interferon-gamma. These results suggest a role for ODC, and therefore polyamines, in the regulation of mononuclear phagocyte functions.
对人单核细胞和小鼠腹腔巨噬细胞中鸟氨酸脱羧酶（ODC）mRNA的积累情况进行了研究。用细菌脂多糖处理这两种单核吞噬细胞群体，可诱导ODC基因转录本的积累显著且快速增加。用人重组干扰素-γ处理人单核细胞后，也观察到了类似现象，尽管不太明显。这些结果表明ODC，进而多胺，在单核吞噬细胞功能的调节中发挥作用。
Zotero 插件