Department of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
Curr Opin Infect Dis. 2011 Apr;24(2):124-9. doi: 10.1097/QCO.0b013e328342cb31.
Clinicians should be aware of the shift in the cutaneous infectious disease burden in human immunodeficiency virus-infected individuals as a reflection of immune restoration in the era of highly active antiretroviral therapy (HAART).
As in the general population but to greater extent, methicillin-resistant Staphylococcus aureus (MRSA) soft-tissue infection is a rising problem among those with human immunodeficiency virus (HIV). Human papilloma virus (HPV) is exceedingly prevalent and persistent despite HAART, and HPV-associated malignancy is increasing as those with HIV live longer. Herpes, syphilis, and Kaposi's sarcoma continue to plague individuals with HIV. Immune reconstitution inflammatory syndrome (IRIS) is common and often presents with infectious cutaneous manifestations.
This review implicates the importance of the acknowledgment of MRSA infections risk factors, screening for HPV-related neoplasia, continuance of trials to establish the efficacy of herpes vaccines, and awareness of prevalent cutaneous infections presenting with IRIS in those with HIV.
随着高效抗逆转录病毒治疗（HAART）时代的到来，HIV 感染者的免疫重建，其皮肤感染性疾病负担也发生了变化，临床医生对此应有认识。
与普通人群一样，但更为严重的是，耐甲氧西林金黄色葡萄球菌（MRSA）软组织感染是 HIV 感染者日益增多的问题。尽管接受了 HAART，人乳头瘤病毒（HPV）仍然非常普遍且持续存在，并且随着 HIV 感染者寿命的延长，HPV 相关恶性肿瘤的发病率也在增加。疱疹、梅毒和卡波西肉瘤继续困扰着 HIV 感染者。免疫重建炎症综合征（IRIS）很常见，常表现为感染性皮肤表现。
本综述表明了以下几点的重要性，包括：承认 MRSA 感染的危险因素、筛查 HPV 相关肿瘤、继续进行疱疹疫苗疗效的试验，以及认识到 HIV 感染者中存在以 IRIS 为表现的常见皮肤感染。
