ENT Department, Hippokration Hospital of Athens, University of Athens, Athens, Greece.
Med Sci Monit. 2011 Jan;17(1):CR42-47. doi: 10.12659/msm.881328.
The probable cause of Benign Paroxysmal Positional Vertigo (BPPV) is a degeneration of the oto lithic organs (utricle and saccule). The aim of the study is to find possible alterations in Vestibular Evoked Myogenic Potentials (VEMP) recordings in BPPV patients, because the saccule is part of the VEMP pathway.
MATERIAL/METHODS: 27 BPPV patients (24 unilateral and 3 bilateral) aged 20 to 70 years and 30 healthy age matched controls. BPPV was diagnosed by the upbeating geotropic nystagmus found in the supine position with the head overextended towards one side. The subjects were investigated with pure tone audiometry, bi-thermal caloric test with electronystagmographic (ENG) recording, and VEMP recording.
P1 latency and N1 latency did not present any statistical difference between control ears and affected ears of the BPPV population. The percentage of abnormal VEMP in the BPPV population was statistically higher than in the control ears (p < 0.005). No significant relationship could be shown between the occurrence of Canal Paresis and abnormal VEMP. No relationship was found between the side (right or left ear) where BPPV appeared clinically and the side where abnormal VEMP was registered.
BPPV is a clinical entity associated with increased occurrence of abnormal VEMP recordings, possibly due to degeneration of the saccular macula, which is part of the neural VEMP pathway.
良性阵发性位置性眩晕（BPPV）的可能病因是耳石器官（椭圆囊和球囊）的退化。本研究的目的是在 BPPV 患者中寻找前庭诱发肌源性电位（VEMP）记录中的可能改变，因为球囊是 VEMP 通路的一部分。
材料/方法：27 名 BPPV 患者（24 名单侧和 3 名双侧），年龄 20-70 岁，30 名年龄匹配的健康对照。BPPV 通过仰卧位时向一侧过度伸展头部时发现的上倾向地性眼球震颤来诊断。对受试者进行纯音听力测试、双侧冷热试验（带有眼震电图（ENG）记录）和 VEMP 记录。
在 BPPV 人群中，对照耳和受累耳的 P1 潜伏期和 N1 潜伏期没有统计学差异。BPPV 人群中异常 VEMP 的百分比明显高于对照组（p < 0.005）。未发现 Canal Paresis 的发生与异常 VEMP 之间存在显著关系。在 BPPV 出现的临床侧（右耳或左耳）和记录到异常 VEMP 的侧之间未发现关系。
BPPV 是一种与异常 VEMP 记录发生率增加相关的临床实体，可能是由于球囊斑的退化所致，球囊斑是神经 VEMP 通路的一部分。
