Lee Jong Dae, Park Moo Kyun, Lee Byung Don, Lee Tae Kyeong, Sung Ki-Bum, Park Ji Yun
Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.
Acta Otolaryngol. 2013 Feb;133(2):150-3. doi: 10.3109/00016489.2012.723823. Epub 2012 Sep 6.
Our results show that cervical vestibular-evoked myogenic potential (cVEMP) or ocular VEMP (oVEMP) abnormalities in the recurrent benign paroxysmal positional vertigo (BPPV) group were significantly higher than those in the non-recurrent BPPV group. Therefore, we can infer that VEMP abnormality is one of risk factors for BPPV recurrence.
This prospective study aimed to test the hypothesis that otolith dysfunction using the VEMP test is a cause of recurrence of BPPV.
cVEMP and oVEMP tests using 500 Hz tone-burst stimuli were performed on 16 patients with recurrent BPPV between March 2010 and December 2011. Both VEMP tests were performed in 20 patients with non-recurrent BPPV.
The differences in age, sex, and involved canal between the recurrent and non-recurrent BPPV groups were not significant. Abnormal cVEMP responses were detected in 5 of 16 (31.3%) subjects in the recurrent BPPV group and abnormal oVMEP responses were detected in 4 of 16 (25%) subjects in the recurrent BPPV group. When we defined VEMP abnormality as an abnormal cVEMP or abnormal oVEMP, VEMP abnormalities were detected in eight (50%) subjects in the recurrent BPPV group and in three (15%) subjects in the non-recurrent BPPV group; the difference between groups was significant.
我们的结果显示，复发性良性阵发性位置性眩晕（BPPV）组的颈前庭诱发肌源性电位（cVEMP）或眼前庭诱发肌源性电位（oVEMP）异常显著高于非复发性BPPV组。因此，我们可以推断VEMP异常是BPPV复发的危险因素之一。
这项前瞻性研究旨在检验以下假设，即使用VEMP测试的耳石功能障碍是BPPV复发的原因。
在2010年3月至2011年12月期间，对16例复发性BPPV患者进行了使用500Hz短纯音刺激的cVEMP和oVEMP测试。对20例非复发性BPPV患者也进行了这两种VEMP测试。
复发性和非复发性BPPV组在年龄、性别和受累半规管方面的差异不显著。复发性BPPV组16名受试者中有5名（31.3%）检测到cVEMP反应异常，16名受试者中有4名（25%）检测到oVMEP反应异常。当我们将VEMP异常定义为cVEMP异常或oVEMP异常时，复发性BPPV组有8名（50%）受试者检测到VEMP异常，非复发性BPPV组有3名（15%）受试者检测到VEMP异常；两组之间的差异具有显著性。
