Denis M, Ghadirian E
Bioscience I, ICI Pharmaceuticals, Macclesfield, U.K.
Immunol Lett. 1990 Jun;24(3):203-6. doi: 10.1016/0165-2478(90)90049-v.
The effect of human recombinant granulocyte-macrophage colony stimulating factor (GM-CSF) on the uptake and intracellular growth of Mycobacterium tuberculosis in human macrophages was investigated. GM-CSF was found to reduce growth of M. tuberculosis in human monocyte-derived macrophages in vitro, as compared to untreated cells. The decrease in intracellular growth of the tubercle bacilli did not depend on generation of reactive oxygen species, inasmuch as treatment with scavengers did not affect the ability of GM-CSF to restrict mycobacterial growth in macrophages.
研究了重组人粒细胞巨噬细胞集落刺激因子（GM-CSF）对人巨噬细胞摄取结核分枝杆菌及结核分枝杆菌在细胞内生长的影响。与未处理的细胞相比，发现GM-CSF可降低结核分枝杆菌在人单核细胞衍生巨噬细胞中的体外生长。结核杆菌细胞内生长的减少并不依赖于活性氧的产生，因为用清除剂处理并不影响GM-CSF限制巨噬细胞中分枝杆菌生长的能力。
