Tarr Philip E, Telenti Amalio
F1000 Med Rep. 2010 Nov 24;2:83. doi: 10.3410/M2-83.
Genetic screening for HIV-related complications is emerging as a clinically relevant prediction tool. A number of single nucleotide polymorphisms associated with conditions such as dyslipidemia and type 2 diabetes have been identified in both the general population and in HIV-infected individuals. Additionally, genome-wide association studies have looked at hepatitis C susceptibility in HIV-infected people, and genetic studies are ongoing for coronary artery disease, osteoporosis, and neurocognitive dysfunction. To date, understanding the contribution of genetic variation to the pathogenesis of lipoatrophy and kidney disease in HIV-infection is limited.
针对与HIV相关并发症的基因筛查正逐渐成为一种具有临床相关性的预测工具。在普通人群和HIV感染者中，均已发现一些与血脂异常和2型糖尿病等病症相关的单核苷酸多态性。此外，全基因组关联研究已着眼于HIV感染者对丙型肝炎的易感性，并且针对冠状动脉疾病、骨质疏松症和神经认知功能障碍的基因研究也正在进行。迄今为止，对于基因变异在HIV感染导致的脂肪萎缩和肾脏疾病发病机制中的作用，人们的了解仍然有限。
