Koshiishi I, Imanari T
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
J Pharmacobiodyn. 1990 Apr;13(4):254-8. doi: 10.1248/bpb1978.13.254.
Cyanate ion is continuously produced by spontaneous degradation of urea both in healthy human blood and in blood of patients with uremia on intermittent hemodialysis. The cyanate ion is trapped irreversibly by amino groups as N-carbamyl groups and reversibly by sulfhydryl groups as S-carbamyl groups. Consequently, these reactions keep the cyanate ion levels in plasma extremely low. Plasma proteins may play an important role in the detoxication of cyanate ion.
在健康人的血液以及接受间歇性血液透析的尿毒症患者的血液中，尿素的自发降解都会持续产生氰酸根离子。氰酸根离子会作为N-氨基甲酰基团被氨基不可逆地捕获，并作为S-氨基甲酰基团被巯基可逆地捕获。因此，这些反应使血浆中的氰酸根离子水平极低。血浆蛋白可能在氰酸根离子的解毒过程中发挥重要作用。
