Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Muscle Nerve. 2011 Jan;43(1):76-81. doi: 10.1002/mus.21847.
Muscle pain is a common side effect of statin medications, but the cause is poorly understood. We characterized phosphocreatine (PCr) exercise recovery kinetics in 10 patients with hypercholesterolemia before and after a 4-week regimen of statin therapy using 31-phosphorus magnetic resonance spectroscopy ((31) P-MRS). (31) P spectra were obtained before, during, and after exercise on a calf flexion pedal ergometer. Creatine kinase (CK) serum levels were drawn before and after statin therapy. The mean metabolic recovery time constant in subjects increased from 28.1 s (SE = 6.5 s) to 55.4 s (SE = 7.4 s) after statin therapy. The unweighted mean of the pre/post-recovery time difference was -27.3 s (SE = 12.4 s; P = 0.02). Pre- and post-therapy CK levels were not significantly different (P = 0.50). Metabolic recovery time in the calf is prolonged in patients after statin use. This suggests that statins impair mitochondrial oxidative function, and (31) P MRS is a potential study model for statin-associated myopathy.
肌肉疼痛是他汀类药物的常见副作用，但病因尚不清楚。我们使用 31 磷磁共振波谱（31 P-MRS）在 10 名高胆固醇血症患者使用他汀类药物治疗 4 周前后，对其肌肉疼痛的磷酸肌酸（PCr）运动恢复动力学进行了特征描述。（31）P 谱在小腿屈伸脚踏功率计运动前、运动中和运动后获得。在他汀类药物治疗前后抽取肌酸激酶（CK）血清水平。与他汀类药物治疗前相比，受试者的平均代谢恢复时间常数从 28.1 秒（SE=6.5 秒）增加到 55.4 秒（SE=7.4 秒）。恢复前/后时间差的未加权平均值为-27.3 秒（SE=12.4 秒；P=0.02）。治疗前后 CK 水平无显著差异（P=0.50）。他汀类药物使用后，小腿的代谢恢复时间延长。这表明他汀类药物会损害线粒体氧化功能，31 P-MRS 是他汀类药物相关肌病的潜在研究模型。
