[The effects of simulated hypoxia on the development of hypothalamic CRF and AVP neurons in postnatal rats].
作者信息
Yang Sheng-mei, Du Ji-zeng
机构信息
College of Biosciences and Biotechnology, Yangzhou University, Yangzhou 225009, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 May;21(2):153-5.
AIM
To investigate the influence of hypoxia on postnatal developing pattern of hypothalamic corticotropin releasing factor(CRF) and arginine vasopressin (AVP) in male and female neonatal rats.
METHODS
The hypoxia was simulated in hypobaric cabin. The content of AVP and CRF was assayed by RIA method.
RESULTS
It was showed the female rats had the similar developing process with male rats, either at 2300 m or at 5000 m altitude. When they developed at simulated 5000 m altitude, the content of their hypothalamic CRF was lower than that of control rats on postnatal day 21, while the content of AVP was higher than control on day 21 and 28.
CONCLUSION
Maybe the difference of the function between hypothalamic CRF and AVP or/and the incoherence of their developing stage contribute to their particular developing pattern at 5000 m altitude.
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