School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.
J Nat Prod. 2011 Jan 28;74(1):50-3. doi: 10.1021/np1005423. Epub 2010 Dec 20.
Three tropane alkaloids, named schizanthines N, O, and P (1-3), have been isolated from the crude alkaloid extract of the endemic Chilean plant Schizanthus tricolor. On the basis of extensive NMR studies and MS fragmentation analysis, their structures were determined to be 3α-(E)-4-hydroxysenecioyloxy-6β-angeloyloxytropane (1), 3α-(E)-4-hydroxysenecioyloxy-6β-senecioyloxytropane (2), and 3α-mesaconyloxy-6β-senecioyloxytropane (3). Compounds 1 and 2 are the first isomeric alkaloids in the tropane series possessing a hydroxysenecioyl substituent as an esterifying moiety.
从智利特有的植物 Schizanthus tricolor 的粗生物碱提取物中分离得到三种托烷生物碱，分别命名为石竹宁 N、O 和 P（1-3）。根据广泛的 NMR 研究和 MS 碎片分析，确定它们的结构分别为 3α-(E)-4-羟基千里光酰氧基-6β-当归酰氧基托烷（1）、3α-(E)-4-羟基千里光酰氧基-6β-千里光酰氧基托烷（2）和 3α-间马钱子酰氧基-6β-千里光酰氧基托烷（3）。化合物 1 和 2 是托烷系列中第一个具有羟千里光酰基作为酯化部分的异构生物碱。
