Herse Fredrik, Reissell Eeva
Nordic Healthcare Group, Helsinki, Finland.
Scand J Infect Dis. 2011 Mar;43(3):209-15. doi: 10.3109/00365548.2010.541492. Epub 2010 Dec 20.
It is known that infections with human papillomavirus (HPV) types 6, 11, 16, and 18, cause cervical cancers (CC), cervical intraepithelial neoplastic lesions (types 1 to 3; CIN 1-3), and genital warts (GW). Together with equivocal cytological abnormalities (ECA), these place a considerable burden on society, but the costs and resource usage are not easily estimated. Therefore, we undertook this study to estimate the burden and costs associated with HPV-related diseases.
We used Finnish registry-based data for CC, CIN 1-3 and ECA. Data on GW were estimated from associated procedures and medications. The annual burden of disease was estimated from hospitalizations, visits to specialists and primary level care, and pharmaceutical use. The evaluation of costs included health care and screening costs, and productivity lost (separately). Due to the data obtained being fragmented, 2 cost scenarios were constructed.
The follow-up of ECA appears to be the most important cost driver. GW should not be underestimated as they affect both genders at an early age.
HPV infections are a burden to society, not only as a result of cancer-related costs, but also costs related to other diseases and indirect costs in the form of lost productivity.
已知人乳头瘤病毒（HPV）6、11、16和18型感染会导致宫颈癌（CC）、宫颈上皮内瘤变（1至3级；CIN 1 - 3）和尖锐湿疣（GW）。这些疾病连同不明确的细胞学异常（ECA）给社会带来了相当大的负担，但成本和资源使用情况不易估算。因此，我们开展了这项研究以估算与HPV相关疾病相关的负担和成本。
我们使用了芬兰基于登记处的数据来研究CC、CIN 1 - 3和ECA。GW的数据是根据相关手术和药物估算得出的。疾病的年度负担是根据住院情况、专科医生和初级保健就诊情况以及药物使用情况估算的。成本评估包括医疗保健和筛查成本，以及分别计算的生产力损失。由于所获得的数据零散，构建了两种成本情景。
对ECA的随访似乎是最重要的成本驱动因素。GW不应被低估，因为它们在早期就会影响两性。
HPV感染给社会带来负担，不仅是因为与癌症相关的成本，还包括与其他疾病相关的成本以及以生产力损失形式存在的间接成本。
