Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Pharmacoeconomics. 2012 Jan;30(1):1-16. doi: 10.2165/11591170-000000000-00000.
External genital warts (EGW) are a sexually transmitted infection caused by various strains of human papillomavirus (HPV). Several studies have described the direct and indirect costs of EGW, while others have reported on the burden of EGW in terms of the impact on the quality of life (QOL) of patients. The arrival of a quadrivalent HPV vaccine that protects against both cervical cancer and EGW requires a proper understanding of the impact of vaccines on costs and QOL. Using pre-defined search terms and inclusion/exclusion criteria, we performed a systematic review of the economic and humanistic burden of EGW. The focus of our review was on literature describing the direct and indirect costs of EGW per episode of care (EoC) or per year, as well as the impact of EGW on disease-specific, generic, or preference-based QOL measures. We also reviewed the literature on the national economic burden of EGW from the perspectives of different countries. Other aspects of EGW management that can inform economic modelling studies, such as length of EoC, number of physician visits and indirect costs, were also explored. Our review sheds light on the high economic and humanistic burden of EGW and important differences in the costs between men and women, as well as the differences in health resource utilization and costs across countries. Our study also highlights the dearth of information on the impact of EGW on the QOL and productivity of patients.
外阴生殖器疣（EGW）是一种由人乳头瘤病毒（HPV）的各种菌株引起的性传播感染。一些研究描述了 EGW 的直接和间接成本，而其他研究则从对患者生活质量（QOL）的影响方面报告了 EGW 的负担。四价 HPV 疫苗的问世既能预防宫颈癌又能预防 EGW，这就需要正确了解疫苗对成本和 QOL 的影响。我们使用预先定义的搜索词和纳入/排除标准，对 EGW 的经济和人文负担进行了系统评价。我们的综述重点是描述每次护理（EoC）或每年 EGW 直接和间接成本的文献，以及 EGW 对疾病特异性、通用或基于偏好的 QOL 测量的影响。我们还审查了从不同国家角度看待 EGW 国家经济负担的文献。还探讨了可以为经济建模研究提供信息的 EGW 管理的其他方面，例如 EoC 的长度、医生就诊次数和间接成本。我们的综述揭示了 EGW 带来的高经济和人文负担，以及男性和女性之间成本的重要差异，以及各国之间卫生资源利用和成本的差异。我们的研究还强调了有关 EGW 对患者 QOL 和生产力影响的信息匮乏。
