Division of Cardiothoracic Surgery, Mount Sinai Medical Center and Heart Institute, Miami Beach, Florida 33140, USA.
Ann Thorac Surg. 2011 Jan;91(1):79-84. doi: 10.1016/j.athoracsur.2010.09.019.
Advanced age is a major predictor of poor outcome in patients undergoing valve surgery. We hypothesized that elderly patients who underwent minimally invasive valve surgery for aortic or mitral valve disease would do better when compared with those undergoing the standard median sternotomy.
We retrospectively reviewed 2,107 consecutive heart operations at our institution and identified 203 patients, age 75 years or greater, who underwent isolated mitral or aortic valve surgery. Outcomes of those who had minimally invasive valve surgery through a right minithoracotomy were compared with those who had a median sternotomy.
Of the 203 patients, 119 (59%) underwent a minimally invasive approach, while 84 (41%) had a median sternotomy. The median postoperative length of stay was 7 days (interquartile range [IQR] 6 to 10) versus 12 days (IQR 9 to 20), p less than 0.001, and intensive care unit length of stay was 52 hours (IQR 44 to 93) versus 119 hours (IQR 57 to 193), p less than 0.001 for minimally invasive and median sternotomy, respectively. In-hospital mortality was 2 (1.7%) versus 8 (9.5%, p=0.01 and composite postoperative morbidity and mortality occurred in 25 (21%) versus 38 (45.2%), p less than 0.001, in minimally invasive versus median sternotomy, respectively. The difference was driven by the following: a lower incidence of acute renal failure, 1 (0.8%) versus 14 (16.7%), p<0.001; prolonged intubation 23 (19.3%) versus 32 (38.1%), p=0.003; wound infections 1 (0.8%) versus 5 (6%), p=0.034; and death.
Minimally invasive surgery for isolated valve lesions in elderly patients yields a lower morbidity and mortality when compared with median sternotomy and should be considered when such individuals require valve surgery.
高龄是接受瓣膜手术患者预后不良的主要预测因素。我们假设,与接受标准正中开胸术的患者相比,接受微创瓣膜手术治疗主动脉瓣或二尖瓣疾病的老年患者会有更好的效果。
我们回顾性分析了我院连续 2107 例心脏手术,确定了 203 例年龄在 75 岁或以上的患者,这些患者接受了单纯二尖瓣或主动脉瓣手术。通过右小开胸术行微创瓣膜手术的患者的转归与行正中开胸术的患者进行了比较。
在 203 例患者中,119 例(59%)采用微创方法,84 例(41%)采用正中开胸术。术后中位住院时间为 7 天(四分位距 [IQR] 6-10)与 12 天(IQR 9-20),p 值均小于 0.001,重症监护病房住院时间为 52 小时(IQR 44-93)与 119 小时(IQR 57-193),p 值均小于 0.001,微创和正中开胸术分别为 52 小时(IQR 44-93)与 119 小时(IQR 57-193)。微创组住院死亡率为 2 例(1.7%),8 例(9.5%),p=0.01;复合术后发病率和死亡率分别为 25 例(21%)和 38 例(45.2%),p 值均小于 0.001,微创组与正中开胸术组分别为 25 例(21%)和 38 例(45.2%)。差异主要归因于以下情况:急性肾衰竭发生率较低,1 例(0.8%)和 14 例(16.7%),p<0.001;长时间插管 23 例(19.3%)和 32 例(38.1%),p=0.003;伤口感染 1 例(0.8%)和 5 例(6%),p=0.034;以及死亡。
与正中开胸术相比,微创瓣膜手术治疗老年患者孤立性瓣膜病变可降低发病率和死亡率,因此对于需要瓣膜手术的此类患者应考虑采用这种手术方式。