BlueLibris, Inc., Menlo Park, CA 94026, USA.
IEEE Trans Biomed Eng. 2011 May;58(5):1373-82. doi: 10.1109/TBME.2010.2100096. Epub 2010 Dec 17.
Obstructive sleep apnea (OSA) is a common disorder associated with anatomical abnormalities of the upper airways that affects 5% of the population. Acoustic parameters may be influenced by the vocal tract structure and soft tissue properties. We hypothesize that speech signal properties of OSA patients will be different than those of control subjects not having OSA. Using speech signal processing techniques, we explored acoustic speech features of 93 subjects who were recorded using a text-dependent speech protocol and a digital audio recorder immediately prior to polysomnography study. Following analysis of the study, subjects were divided into OSA (n=67) and non-OSA (n=26) groups. A Gaussian mixture model-based system was developed to model and classify between the groups; discriminative features such as vocal tract length and linear prediction coefficients were selected using feature selection technique. Specificity and sensitivity of 83% and 79% were achieved for the male OSA and 86% and 84% for the female OSA patients, respectively. We conclude that acoustic features from speech signals during wakefulness can detect OSA patients with good specificity and sensitivity. Such a system can be used as a basis for future development of a tool for OSA screening.
阻塞性睡眠呼吸暂停(OSA)是一种常见的疾病,与上呼吸道的解剖异常有关,影响 5%的人口。声学参数可能受到声道结构和软组织特性的影响。我们假设 OSA 患者的语音信号特征与没有 OSA 的对照组不同。使用语音信号处理技术,我们研究了 93 名受试者的语音特征,这些受试者使用依赖文本的语音协议和数字音频记录器在多导睡眠图研究之前进行了记录。在对研究进行分析后,我们将受试者分为 OSA(n=67)和非 OSA(n=26)两组。我们开发了一个基于高斯混合模型的系统来对两组进行建模和分类;使用特征选择技术选择了声道长度和线性预测系数等有区别的特征。男性 OSA 患者的特异性和敏感性分别为 83%和 79%,女性 OSA 患者的特异性和敏感性分别为 86%和 84%。我们得出结论,清醒状态下语音信号的声学特征可以很好地特异性和敏感性地检测出 OSA 患者。这样的系统可以作为未来开发 OSA 筛查工具的基础。