Dementia Research Centre, Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3BG, UK.
J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1341-3. doi: 10.1136/jnnp.2010.227983. Epub 2010 Dec 16.
Impairments of face processing occur frequently in frontotemporal lobar degeneration (FTLD) but the neuroanatomical basis for these deficits has seldom been studied systematically. Here a prospective voxel based morphometry study is described addressing the neuroanatomy of two key dimensions of face processing--face identification and facial emotion recognition--in a single cohort of 32 patients with FTLD (19 with frontal variant and 13 with temporal variant FTLD). For the FTLD group as a whole, face identification was positively associated with grey matter in the right anterior fusiform gyrus while recognition of angry expressions was positively associated with grey matter in the bilateral insula cortex. FTLD provides a perspective on the neuroanatomy of face processing that is complementary to focal lesion and normal functional imaging work.
在额颞叶变性（FTLD）中经常出现面部处理损伤，但这些缺陷的神经解剖基础很少被系统地研究。这里描述了一项前瞻性基于体素的形态计量学研究，该研究针对面部处理的两个关键维度——面部识别和面部情绪识别——在一个由 32 名 FTLD 患者（19 名额变异型和 13 名颞变异型 FTLD）组成的单一队列中进行了研究。对于整个 FTLD 组，面部识别与右侧前梭状回的灰质呈正相关，而识别愤怒表情与双侧岛叶皮层的灰质呈正相关。FTLD 为面部处理的神经解剖学提供了一个与局灶性病变和正常功能成像工作互补的视角。
