Cohen Miriam H, Carton Amelia M, Hardy Christopher J, Golden Hannah L, Clark Camilla N, Fletcher Phillip D, Jaisin Kankamol, Marshall Charles R, Henley Susie M D, Rohrer Jonathan D, Crutch Sebastian J, Warren Jason D
Dementia Research Centre, UCL Institute of Neurology, Department of Neurodegenerative Disease, University College London, London, United Kingdom.
Dementia Research Centre, UCL Institute of Neurology, Department of Neurodegenerative Disease, University College London, London, United Kingdom.
Neuropsychologia. 2016 Jan 29;81:245-254. doi: 10.1016/j.neuropsychologia.2015.12.031. Epub 2015 Dec 31.
art may signal emotions independently of a biological or social carrier: it might therefore constitute a test case for defining brain mechanisms of generic emotion decoding and the impact of disease states on those mechanisms. This is potentially of particular relevance to diseases in the frontotemporal lobar degeneration (FTLD) spectrum. These diseases are often led by emotional impairment despite retained or enhanced artistic interest in at least some patients. However, the processing of emotion from art has not been studied systematically in FTLD. Here we addressed this issue using a novel emotional valence matching task on abstract paintings in patients representing major syndromes of FTLD (behavioural variant frontotemporal dementia, n=11; sematic variant primary progressive aphasia (svPPA), n=7; nonfluent variant primary progressive aphasia (nfvPPA), n=6) relative to healthy older individuals (n=39). Performance on art emotion valence matching was compared between groups taking account of perceptual matching performance and assessed in relation to facial emotion matching using customised control tasks. Neuroanatomical correlates of art emotion processing were assessed using voxel-based morphometry of patients' brain MR images. All patient groups had a deficit of art emotion processing relative to healthy controls; there were no significant interactions between syndromic group and emotion modality. Poorer art emotion valence matching performance was associated with reduced grey matter volume in right lateral occopitotemporal cortex in proximity to regions previously implicated in the processing of dynamic visual signals. Our findings suggest that abstract art may be a useful model system for investigating mechanisms of generic emotion decoding and aesthetic processing in neurodegenerative diseases.
因此，它可能成为定义一般情感解码的大脑机制以及疾病状态对这些机制影响的一个测试案例。这可能与额颞叶变性（FTLD）谱系中的疾病特别相关。这些疾病通常以情感障碍为先导，尽管至少在一些患者中艺术兴趣得以保留或增强。然而，FTLD患者对艺术中情感的处理尚未得到系统研究。在此，我们针对代表FTLD主要综合征的患者（行为变异型额颞叶痴呆，n = 11；语义变异型原发性进行性失语（svPPA），n = 7；非流利变异型原发性进行性失语（nfvPPA），n = 6），相对于健康老年人（n = 39），使用一项针对抽象画的新颖情感效价匹配任务来解决这个问题。在考虑感知匹配表现的情况下，比较了两组在艺术情感效价匹配方面的表现，并使用定制的对照任务与面部情感匹配进行评估。使用患者脑磁共振图像的基于体素的形态测量法评估艺术情感处理的神经解剖学相关性。所有患者组相对于健康对照组在艺术情感处理方面均存在缺陷；综合征组与情感模态之间没有显著交互作用。较差的艺术情感效价匹配表现与右侧枕颞外侧皮质灰质体积减少有关，该区域靠近先前涉及动态视觉信号处理的区域。我们的研究结果表明，抽象艺术可能是研究神经退行性疾病中一般情感解码和审美处理机制的一个有用模型系统。
