Savvov V I, Karpov L M
Vopr Onkol. 1978;24(8):97-9.
The rate of pyruvic acid oxidation by human mammary gland tumor homogenates is several times lower compared with that by homogenates of the adjacent non-involved tissues. This dependence is especially manifest with malignant tumors, although in this case both in the involved and non-involved tissues the pyruvate oxidation is slower than in benign tumors. In the in vitro experiments the rate of S35 lipoic acid binding by the precipitated in 10000 g fractions of the homogenates in question was the highest for malignant tumors and 3.36 times lower for the adjacent tissues. In benign tumors these values and their correlation were much more lower.
人乳腺肿瘤匀浆对丙酮酸的氧化速率比相邻未受累组织的匀浆低几倍。这种依赖性在恶性肿瘤中尤为明显，尽管在这种情况下，受累组织和未受累组织中的丙酮酸氧化都比良性肿瘤中的慢。在体外实验中，在所讨论的匀浆经10000g离心后的沉淀部分中，恶性肿瘤对S35硫辛酸的结合速率最高，相邻组织的结合速率低3.36倍。在良性肿瘤中，这些值及其相关性要低得多。
