Karpov L M, Dvuzhil'naia E D, Savvov V I
Vopr Onkol. 1977;23(10):87-90.
S35-lipoic acid injected intraperitoneally in rats with Walker carcinosarcoma in a dose of 250 mg/Kg is accumulated in their organs and tissues to much higher concentrations compared with normal animals during all terms of the observation (15 min, 1 hour, 24 hours). Differences were especially great after 24 hours. Pyruvate dehydrogenase activity in tumor rats organs was considerably reduced when calculated per 1 Kg of tissue, but it is practically unchanged when calculated per 1 mg of protein, which amount in 1 g of tissue in them is distinctly lower than in normal animals. Single injections of lipoic acid in tumor-bearing rats do restore the enzyme activity to normal (in 1 hour), while repeated ones (10 days)--prolong animals lifeterms by 25%.
以250毫克/千克的剂量腹腔注射到患有沃克癌肉瘤的大鼠体内的S35 -硫辛酸，在整个观察期（15分钟、1小时、24小时）内，其在大鼠器官和组织中的蓄积浓度比正常动物高得多。24小时后差异尤为显著。肿瘤大鼠器官中的丙酮酸脱氢酶活性，以每1千克组织计算时显著降低，但以每1毫克蛋白质计算时实际上没有变化，肿瘤大鼠1克组织中的蛋白质含量明显低于正常动物。给荷瘤大鼠单次注射硫辛酸可使酶活性恢复正常（1小时内），而重复注射（10天）可使动物寿命延长25%。
