Kawada N, Mizoguchi Y, Sakagami Y, Kobayashi K, Yamamoto S, Morisawa S
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1990 Jun;40(2):149-55. doi: 10.1016/0952-3278(90)90158-h.
When heat-killed Propionibacterium acnes is intravenously injected into rats followed by an intravenous injection of a small amount of Gram-negative lipopolysaccharide (LPS) 7 days later, massive hepatic cell necrosis is induced and most of the rats die within 24 hours of LPS injection. Using this experimental model, we studied the changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue and bile of rats with experimentally-induced massive hepatic cell necrosis. Both the levels of LTs and PGs in the liver tissue and LTs in the bile increased before the microscopic appearance of hepatic cell necrosis. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury.
当将热灭活的痤疮丙酸杆菌静脉注射到大鼠体内，7天后再静脉注射少量革兰氏阴性脂多糖（LPS）时，会诱导大量肝细胞坏死，并且大多数大鼠在注射LPS后的24小时内死亡。利用这个实验模型，我们研究了实验性诱导大量肝细胞坏死的大鼠肝脏组织和胆汁中白三烯（LTs）和前列腺素（PGs）水平的变化。在肝细胞坏死的显微镜下表现出现之前，肝脏组织中的LTs和PGs水平以及胆汁中的LTs水平均升高。这些结果表明，花生四烯酸代谢产物可能在肝细胞损伤的诱导中起重要作用。
