Kawada N, Mizoguchi Y, Kobayashi K, Yamamoto S, Morisawa S
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Gastroenterol Jpn. 1990 Jun;25(3):363-8. doi: 10.1007/BF02779452.
The changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue of rats with carbon tetrachloride (CCl4)-induced liver injury were studied. As a result, after the administration of CCl4, the levels of LTs increased at an early stage while the levels of PGs increased at a later stage. This suggests that LTs may have an adverse effect on liver injury induced by CCl4, and that PGs may not have a direct effect on liver injury. In addition, serum GOT and GPT levels improved with the administration of AA-861, a 5-lipoxygenase inhibitor, while these levels did not change with the administration of indomethacin, a cyclooxygenase inhibitor. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury.
研究了四氯化碳（CCl4）诱导肝损伤大鼠肝组织中白三烯（LTs）和前列腺素（PGs）水平的变化。结果显示，给予CCl4后，LTs水平在早期升高，而PGs水平在后期升高。这表明LTs可能对CCl4诱导的肝损伤有不利影响，而PGs可能对肝损伤没有直接影响。此外，给予5-脂氧合酶抑制剂AA-861后，血清谷草转氨酶（GOT）和谷丙转氨酶（GPT）水平有所改善，而给予环氧化酶抑制剂吲哚美辛后，这些水平没有变化。这些结果表明，花生四烯酸代谢产物可能在诱导肝细胞损伤中起重要作用。
