CICR takes centre stage in {beta}-cells: a cute cascade connects cAMP to CICR.
作者信息
Islam Md Shahidul
机构信息
Department of Clinical Sciences and Education, Karolinska Institutet, Södersjukhuset, 118 83 Stockholm, Sweden.
出版信息
J Physiol. 2010 Dec 15;588(Pt 24):4853. doi: 10.1113/jphysiol.2010.202291.
Abstract
摘要
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CICR takes centre stage in {beta}-cells: a cute cascade connects cAMP to CICR.钙诱导钙释放（CICR）在β细胞中占据核心地位：一个精妙的级联反应将环磷酸腺苷（cAMP）与CICR相连。
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An estimated 285 million people in the world have islet failure.
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Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.胰高血糖素样肽-1 受体激动剂 exendin-4 通过 Epac2 依赖性细胞内 Ca²+动员在 PLC-ε 基因敲除小鼠的β细胞中被破坏。
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3
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.交换蛋白直接激活剂（Epac）和磷脂酶Cε通过激活蛋白激酶Cε和钙调蛋白激酶II来调节心脏中的钙离子释放。
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Glycolytic pathway intermediates activate cardiac ryanodine receptors.糖酵解途径中间体激活心肌兰尼碱受体。
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