Abalakin V A, Buravtseva N P, Cherkasskiĭ B L
Zh Mikrobiol Epidemiol Immunobiol. 1990 May(5):72-5.
The preparation of low-molecular protective antigen (PA) isolated from strain 34F2 (Sterne) and having a molecular weight of 34 and 51 kD, unlike the preparation of high-molecular PA with a molecular weight of 87 kD, suppressed the formation of acquired resistance to anthrax when introduced into guinea pigs in mixture with live spores of strains of STI, 34F2 and new vaccine strain 228/8; this phenomenon was mainly accompanied by a decrease in the level of antibodies to lethal factor (LF) nad in the antitoxic activity of blood serum. The immunosuppressing action of low-molecular PA depended on the kind of vaccine strain introduced together with this antigen, which suggested the existence of differences in the ligand determinants of strains 34F2 and STI. In contrast to high-molecular PA, low-molecular PA blocked the action of the lethal mixture of PA and LF on the culture of peritoneal mononuclear phagocytes of CBA mice. The competitive relationships between low-molecular PA and high-molecular PA are discussed.
从34F2（斯特恩）菌株分离出的分子量为34和51千道尔顿的低分子保护性抗原（PA）制剂，与分子量为87千道尔顿的高分子PA制剂不同，当与STI、34F2菌株的活孢子和新疫苗菌株228/8混合引入豚鼠体内时，可抑制对炭疽的获得性抗性形成；这种现象主要伴随着血清中抗致死因子（LF）抗体水平和抗毒活性的降低。低分子PA的免疫抑制作用取决于与该抗原一起引入的疫苗菌株种类，这表明34F2和STI菌株的配体决定簇存在差异。与高分子PA相反，低分子PA可阻断PA和LF致死混合物对CBA小鼠腹腔单核吞噬细胞培养物的作用。文中讨论了低分子PA和高分子PA之间的竞争关系。
