用产生保护性抗原的减毒重组炭疽芽孢杆菌菌株进行炭疽疫苗接种。
Vaccination against anthrax with attenuated recombinant strains of Bacillus anthracis that produce protective antigen.
作者信息
Barnard J P, Friedlander A M
机构信息
Division of Bacteriology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011, USA.
出版信息
Infect Immun. 1999 Feb;67(2):562-7. doi: 10.1128/IAI.67.2.562-567.1999.
Abstract
The protective efficacy of several live, recombinant anthrax vaccines given in a single-dose regimen was assessed with Hartley guinea pigs. These live vaccines were created by transforming DeltaANR and DeltaSterne, two nonencapsulated, nontoxinogenic strains of Bacillus anthracis, with four different recombinant plasmids that express the anthrax protective antigen (PA) protein to various degrees. This enabled us to assess the effect of the chromosomal background of the strain, as well as the amount of PA produced, on protective efficacy. There were no significant strain-related effects on PA production in vitro, plasmid stability in vivo, survival of the immunizing strain in the host, or protective efficacy of the immunizing infection. The protective efficacy of the live, recombinant anthrax vaccine strains correlated with the anti-PA antibody titers they elicited in vivo and the level of PA they produced in vitro.
摘要
采用哈特利豚鼠评估了几种单剂量方案的活体重组炭疽疫苗的保护效力。这些活疫苗是通过用四种不同的重组质粒转化炭疽芽孢杆菌的两种非包膜、无毒素生成菌株DeltaANR和DeltaSterne构建而成的，这四种重组质粒能不同程度地表达炭疽保护性抗原（PA）蛋白。这使我们能够评估菌株的染色体背景以及产生的PA量对保护效力的影响。在体外PA产生、体内质粒稳定性、免疫菌株在宿主体内的存活或免疫感染的保护效力方面，未观察到与菌株相关的显著影响。活体重组炭疽疫苗株的保护效力与其在体内引发的抗PA抗体滴度以及在体外产生的PA水平相关。
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