接受血液透析的慢性尿毒症患者血清对体外BFU-E生长及T淋巴细胞爆式促进活性的抑制作用。
Inhibition of BFU-E in vitro growth and of burst-promoting activity of T lymphocytes by serum of chronic uremic patients receiving hemodialysis.
作者信息
Morra L, Ponassi A, Moccia F, Gurreri G, Bessone G, Mela G S, Sacchetti C
机构信息
Istituto Scientifico di Medicina Interna, Università di Genova, Italia.
出版信息
Acta Haematol. 1990;84(1):14-8. doi: 10.1159/000205020.
The effects of uremic serum on the in vitro growth of normal BFU-E and on the burst-promoting activity by normal T-lymphocytes were evaluated separately. The effect of hemodialysis on the removal of possible serum inhibitor(s) was also tested. Sera of 12 uremic patients were shown to provoke a 60% inhibition of the in vitro growth of normal BFU-E and almost complete abolition of burst-promoting activity by T lymphocytes. While hemodialysis significantly removed the inhibition of uremic sera on BFU-E growth, it was rather ineffective in removing the inhibitor(s) of T lymphocytes. The different effects of uremic serum on BFU-E and on T lymphocytes are discussed.
分别评估了尿毒症血清对正常爆式红系集落形成单位（BFU-E）体外生长的影响以及对正常T淋巴细胞爆式促进活性的影响。还测试了血液透析对去除可能存在的血清抑制剂的效果。结果显示，12例尿毒症患者的血清可使正常BFU-E的体外生长受到60%的抑制，并且几乎完全消除T淋巴细胞的爆式促进活性。虽然血液透析能显著消除尿毒症血清对BFU-E生长的抑制作用，但在去除T淋巴细胞抑制剂方面效果甚微。文中讨论了尿毒症血清对BFU-E和T淋巴细胞的不同影响。
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