受体型鸟苷酸环化酶是秀丽隐杆线虫感知二氧化碳所必需的。
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
机构信息
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):254-9. doi: 10.1073/pnas.1017354108. Epub 2010 Dec 20.
Abstract
CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO(2) sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO(2).
摘要
二氧化碳既是动物生理学的重要调节因子，也是许多动物探测宿主、定位食物和寻找配偶的重要感官提示。自由生活的土壤线虫秀丽隐杆线虫表现出对二氧化碳的回避行为，这需要一对有纤毛的感觉神经元，BAG 神经元。通过体内钙成像，我们发现二氧化碳特异性地激活 BAG 神经元，而 BAG 神经元的二氧化碳感应功能需要 TAX-2/TAX-4 环核苷酸门控离子通道和受体型鸟苷酸环化酶 GCY-9。我们的结果描绘了一条二氧化碳感应的分子途径，并表明激活受体型鸟苷酸环化酶是动物探测环境二氧化碳的一种保守机制。
相似文献
1
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.受体型鸟苷酸环化酶是秀丽隐杆线虫感知二氧化碳所必需的。
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):254-9. doi: 10.1073/pnas.1017354108. Epub 2010 Dec 20.
2
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.由秀丽隐杆线虫鸟苷酸环化酶同源物介导的氧气感知和群体进食行为
Nature. 2004 Jul 15;430(6997):317-22. doi: 10.1038/nature02714. Epub 2004 Jun 27.
3
Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.线虫中平行的活性依赖途径对神经肽表达的控制。
Sci Rep. 2017 Jan 31;7:38734. doi: 10.1038/srep38734.
4
Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.线虫跨膜鸟苷酸环化酶 GCY-14 介导的环境碱度感应。
Curr Biol. 2013 Jun 3;23(11):1007-12. doi: 10.1016/j.cub.2013.04.052. Epub 2013 May 9.
5
A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity.一个 ETS 家族转录因子的单一基因靶标决定了神经元的 CO2 化学敏感性。
PLoS One. 2012;7(3):e34014. doi: 10.1371/journal.pone.0034014. Epub 2012 Mar 29.
6
A chemoreceptor that detects molecular carbon dioxide.一种能检测分子二氧化碳的化学感受器。
J Biol Chem. 2013 Dec 27;288(52):37071-81. doi: 10.1074/jbc.M113.517367. Epub 2013 Nov 15.
7
Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.秀丽隐杆线虫的偏侧化味觉行为由特定的受体型鸟苷酸环化酶控制。
Curr Biol. 2009 Jun 23;19(12):996-1004. doi: 10.1016/j.cub.2009.05.043. Epub 2009 Jun 11.
8
Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans.定义 cGMP 介导的秀丽隐杆线虫味觉感觉转导的特异性决定因素。
Genetics. 2013 Aug;194(4):885-901. doi: 10.1534/genetics.113.152660. Epub 2013 May 20.
9
Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans.可溶性鸟苷酸环化酶信号传导与神经肽之间的协同作用可延长线虫秀丽隐杆线虫的寿命。
Aging Cell. 2017 Apr;16(2):401-413. doi: 10.1111/acel.12569. Epub 2017 Jan 4.
10
A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.一种行为转变：嗅觉神经元中的cGMP和PKC信号传导逆转了秀丽隐杆线虫的气味偏好。
Neuron. 2008 Sep 25;59(6):959-71. doi: 10.1016/j.neuron.2008.07.038.
引用本文的文献
1
Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode .环核苷酸磷酸二酯酶在线虫信号转导途径中的作用
Cells. 2025 Jul 30;14(15):1174. doi: 10.3390/cells14151174.
2
Food sensing controls reproductive behavior by neuromodulatory disinhibition.食物感知通过神经调节性去抑制来控制生殖行为。
Sci Adv. 2025 Apr 18;11(16):eadu5829. doi: 10.1126/sciadv.adu5829. Epub 2025 Apr 16.
3
Carbon dioxide shapes parasite-host interactions in a human-infective nematode.二氧化碳塑造了一种人类感染性线虫中的寄生虫与宿主的相互作用。
Curr Biol. 2025 Jan 20;35(2):277-286.e6. doi: 10.1016/j.cub.2024.11.036. Epub 2024 Dec 23.
4
C. elegans PPEF-type phosphatase (Retinal degeneration C ortholog) functions in diverse classes of cilia to regulate nematode behaviors.秀丽隐杆线虫 PPEF 型磷酸酶（视网膜退行性变 C 同源物）在多种纤毛类群中发挥作用，以调节线虫行为。
Sci Rep. 2024 Nov 16;14(1):28347. doi: 10.1038/s41598-024-79057-z.
5
Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.秀丽隐杆线虫的神经肽信号网络：从结构到行为。
Genetics. 2024 Nov 6;228(3). doi: 10.1093/genetics/iyae141.
6
Advanced Neural Functional Imaging in Using Lab-on-a-Chip Technology.利用芯片实验室技术的先进神经功能成像
Micromachines (Basel). 2024 Aug 12;15(8):1027. doi: 10.3390/mi15081027.
7
neuropeptide NLP-27 enhances neurodegeneration and paralysis in an opioid-like manner during fungal infection.神经肽NLP-27在真菌感染期间以类阿片样方式增强神经变性和麻痹。
iScience. 2024 Mar 12;27(4):109484. doi: 10.1016/j.isci.2024.109484. eCollection 2024 Apr 19.
8
Carbon dioxide shapes parasite-host interactions in a human-infective nematode.二氧化碳塑造了一种人类感染性线虫中的寄生虫与宿主的相互作用。
bioRxiv. 2024 Mar 31:2024.03.28.587273. doi: 10.1101/2024.03.28.587273.
9
Effect of Guanylate Cyclase-22-like on Ovarian Development of (Hemiptera: Anthocoridae).鸟苷酸环化酶-22样蛋白对小花蝽卵巢发育的影响（半翅目：花蝽科）
Insects. 2024 Feb 4;15(2):110. doi: 10.3390/insects15020110.
10
Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegans.在不同的生命周期中，秀丽隐杆线虫通过不同的神经遗传机制建立相同的化学感觉效价状态。
G3 (Bethesda). 2024 Feb 7;14(2). doi: 10.1093/g3journal/jkad271.
本文引用的文献
1
The structure of the nervous system of the nematode Caenorhabditis elegans.秀丽隐杆线虫的神经系统结构。
Philos Trans R Soc Lond B Biol Sci. 1986 Nov 12;314(1165):1-340. doi: 10.1098/rstb.1986.0056.
2
Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans olfactory neurons.神经肽反馈调节秀丽隐杆线虫嗅觉神经元中海马体诱发的动力学。
Nat Neurosci. 2010 May;13(5):615-21. doi: 10.1038/nn.2526. Epub 2010 Apr 4.
3
Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila.果蝇气味感知和 CO2 感知神经元中 G 蛋白的作用。
J Neurosci. 2010 Mar 31;30(13):4562-72. doi: 10.1523/JNEUROSCI.6357-09.2010.
4
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.杏仁核是一种化学感受器，可检测二氧化碳和酸中毒以引发恐惧行为。
Cell. 2009 Nov 25;139(5):1012-21. doi: 10.1016/j.cell.2009.10.029.
5
Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans.两种化学感受器介导 dauer 信息素在秀丽隐杆线虫中的发育效应。
Science. 2009 Nov 13;326(5955):994-8. doi: 10.1126/science.1176331. Epub 2009 Oct 1.
6
Neural detection of gases--carbon dioxide, oxygen--in vertebrates and invertebrates.脊椎动物和无脊椎动物对气体——二氧化碳、氧气——的神经检测。
Curr Opin Neurobiol. 2009 Aug;19(4):354-61. doi: 10.1016/j.conb.2009.06.010. Epub 2009 Jul 27.
7
Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.秀丽隐杆线虫的偏侧化味觉行为由特定的受体型鸟苷酸环化酶控制。
Curr Biol. 2009 Jun 23;19(12):996-1004. doi: 10.1016/j.cub.2009.05.043. Epub 2009 Jun 11.
8
Stimulation of guanylyl cyclase-D by bicarbonate.碳酸氢盐对鸟苷酸环化酶-D的刺激作用。
Biochemistry. 2009 May 26;48(20):4417-22. doi: 10.1021/bi900441v.
9
Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases.神经元利用不同的鸟苷酸环化酶来检测氧气水平的升高和降低。
Neuron. 2009 Mar 26;61(6):865-79. doi: 10.1016/j.neuron.2009.02.013.
10
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans.二氧化碳水平升高会影响秀丽隐杆线虫的发育、运动能力和繁殖力，并延长其寿命。
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4024-9. doi: 10.1073/pnas.0900309106. Epub 2009 Feb 23.
Zotero 插件