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青少年特发性脊柱侧凸（AIS）预后基因检测的最新进展。

Update on prognostic genetic testing in adolescent idiopathic scoliosis (AIS).

作者信息

Ogilvie James W

机构信息

Genetics Research Laboratory, Axial Biotech, Inc., Salt Lake City, UT 84109, USA.

出版信息

J Pediatr Orthop. 2011 Jan-Feb;31(1 Suppl):S46-8. doi: 10.1097/BPO.0b013e3181fd87eb.

DOI:10.1097/BPO.0b013e3181fd87eb
PMID:21173618
Abstract

Case-control genome-wide association studies using a large, geographically diverse data base has been used to identify single nucleotide polymorphisms that have prognostic utility in predicting progression of mild adolescent idiopathic scoliosis in White patients. The calculated risk of progression score allows stratification of patients that can make medical care evidence based, less costly, and more efficient.

摘要

利用一个庞大的、地域多样的数据库进行病例对照全基因组关联研究，已用于识别在预测白人青少年特发性脊柱侧弯患者病情进展方面具有预后效用的单核苷酸多态性。计算得出的病情进展风险评分能够对患者进行分层，从而使医疗护理基于证据、成本更低且效率更高。

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