Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
J Glaucoma. 2012 Feb;21(2):116-22. doi: 10.1097/IJG.0b013e31820277da.
To assess and compare the influence of cataract on measurements of retinal nerve fiber layer (RNFL) thickness by time domain (TD) optical coherence tomography (OCT) and spectral domain (SD) OCT.
Patients who underwent uncomplicated cataract surgery were consecutively enrolled in this study. The peripapillary RNFL thickness was measured before and 8 weeks after cataract surgery using TD-OCT and SD-OCT during the same visit. Changes in the RNFL thickness measurement and signal strength (SS) after cataract surgery were evaluated.
A total of 54 patients (54 eyes) were included. After excluding 19 eyes owing to poor imaging or low SS (<5), scans of 35 eyes were included in the final analysis. A significant difference was identified between the preoperative and postoperative SS values using SD-OCT, but not TD-OCT (P=0.002 and 0.789, respectively). The changes in RNFL thickness after cataract surgery were more prominent and frequent for SD-OCT than TD-OCT. There was a significant correlation between change in preoperative RNFL thickness and SS changes for both TD-OCT (r=0.410, P<0.001) and SD-OCT (r=0.246, P=0.002).
The presence of cataract significantly affects RNFL thickness measurements by SD-OCT and TD-OCT. SD-OCT, which demonstrated more consistent change of RNFL measurements after cataract extraction, is not necessarily associated with lower RNFL thickness measurement performance in cataract cases, as more participants with cataract were excluded because of poor image quality or low SS, which was more associated with TD-OCT than SD-OCT.
评估并比较时域（TD）光学相干断层扫描（OCT）和谱域（SD）OCT 对白内障患者视网膜神经纤维层（RNFL）厚度测量的影响。
本研究连续纳入接受单纯白内障手术的患者。在同一次就诊中，使用 TD-OCT 和 SD-OCT 分别在白内障手术前和手术后 8 周测量视盘周围 RNFL 厚度。评估白内障手术后 RNFL 厚度测量值和信号强度（SS）的变化。
共纳入 54 例（54 只眼）患者。排除 19 只眼图像质量差或 SS 低（<5）后，最终纳入 35 只眼进行分析。SD-OCT 检测到术前和术后 SS 值有显著差异，但 TD-OCT 无显著差异（分别为 P=0.002 和 0.789）。白内障手术后，SD-OCT 比 TD-OCT 检测到的 RNFL 厚度变化更显著且更频繁。TD-OCT（r=0.410，P<0.001）和 SD-OCT（r=0.246，P=0.002）的术前 RNFL 厚度变化与 SS 变化之间均存在显著相关性。
白内障的存在显著影响 SD-OCT 和 TD-OCT 的 RNFL 厚度测量值。SD-OCT 检测到白内障摘除后 RNFL 测量值的变化更一致，但与白内障病例的 RNFL 厚度测量性能下降不一定相关，因为更多的白内障患者因图像质量差或 SS 低而被排除在外，而这与 TD-OCT 的相关性大于 SD-OCT。
