Kanner Andres M
Rush Medical College at Rush University, Laboratory of Electroencephalography and Video-EEG-Telemetry, Section of Epilepsy and Rush Epilepsy Center, Rush University Medical Center 1653 West Congress Parkway, Chicago, IL 60612 USA.
F1000 Med Rep. 2010 Jul 14;2:51. doi: 10.3410/M2-51.
The purpose of this brief article is to review old concepts of the significance of acute symptomatic seizures, the impact of psychiatric comorbidities on the response of pharmacologic and surgical treatments of the seizure disorder, and the importance of factoring comorbid medical comorbidities into the choice of antiepileptic drugs (AEDs). In addition, this article provides an update on the latest data on the teratogenic effects of AEDs and reviews the most relevant results of a recent practice guideline on pregnancy issues in women with epilepsy. The article closes with a review of the latest advances in the therapeutic effects of first- and second-generation AEDs.
这篇短文的目的是回顾关于急性症状性癫痫发作意义的旧有概念、精神共病对癫痫障碍药物和手术治疗反应的影响，以及在选择抗癫痫药物（AEDs）时考虑合并内科疾病的重要性。此外，本文还提供了AEDs致畸作用的最新数据更新，并回顾了近期关于癫痫女性妊娠问题实践指南的最相关结果。文章最后回顾了第一代和第二代AEDs治疗效果的最新进展。
