对天然化学连接中肽脯氨酰硫酯反应性显著降低的起源进行调查。
An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation.
机构信息
Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Chem Commun (Camb). 2011 Feb 28;47(8):2342-4. doi: 10.1039/c0cc04120c. Epub 2010 Dec 21.
PMID:21173985
Abstract
The low reactivity of peptide-prolyl-thioesters in native chemical ligation is not due to steric effects at the β-carbon, but rather to the presence of a carbonyl moiety on the nitrogen atom of the proline.
摘要
在天然化学连接中，肽-脯氨酰-硫酯的低反应活性不是由于β-碳上的空间位阻效应，而是由于脯氨酸氮原子上存在羰基部分。
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