一种烯炔环异构化方法用于三重再摄取抑制剂 GSK1360707F。

An enyne cycloisomerization approach to the triple reuptake inhibitor GSK1360707F.

机构信息

Chemical Development, GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, North Carolina 27709, United States.

出版信息

J Org Chem. 2011 Jan 21;76(2):712-5. doi: 10.1021/jo102098y. Epub 2010 Dec 21.

DOI:10.1021/jo102098y

Abstract

The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial enantioselectivity studies are discussed.

摘要

三重再摄取抑制剂 GSK1360707F 是通过一种高效且可扩展的路线合成的，该路线的特点是使用 Pt(II) 或 Au(I) 催化的炔烃环异构化反应。本文讨论了这项工作的关键方面，如氮保护基团的选择和初始对映选择性研究。