Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Brazil.
Aust N Z J Psychiatry. 2011 Jan;45(1):76-85. doi: 10.3109/00048674.2010.527822.
To investigate whether patients who develop obsessive-compulsive disorder (OCD) after posttraumatic stress disorder, i.e. post-traumatic OCD (PsT-OCD), display a distinctive neurocognitive pattern of dysfunction.
Patients with PsT-OCD (n = 16), pre-traumatic OCD (PrT-OCD) (n = 18), non-traumatic OCD (NonT-OCD) (n = 67) and healthy controls (n = 17) had their performance compared on the following neuropsychological tests: the Wisconsin Card Sorting Test, the Iowa Gambling Task, the Wechsler Memory Scale Logical Memory, the Brief Visual Memory Test - Revised, and the Wechsler Abbreviated Scale for Intelligence.
Patients with OCD, as a group, were characterized by poor set-shifting abilities and impaired verbal and visuospatial memories. Impaired set-shifting abilities were found to correlate with the severity of obsessive-compulsive symptoms in all groups of patients with OCD, with the exception of PsT-OCD. Only patients with PsT-OCD were characterized by impaired visuospatial recognition, which was found to correlate with poor set-shifting abilities in this particular group of patients, but not in individuals with other types of OCD or in healthy controls.
Our study suggests that PsT-OCD is associated with a distinctive pattern of neurocognitive dysfunction, thus providing support for a different subtype of OCD.
探究创伤后应激障碍后发生强迫症（OCD），即创伤后 OCD（PsT-OCD）的患者是否表现出明显的神经认知功能障碍模式。
将 16 例 PsT-OCD 患者、18 例 PrT-OCD 患者、67 例 NonT-OCD 患者和 17 例健康对照组进行比较，比较以下神经心理学测试的表现：威斯康星卡片分类测试、爱荷华赌博任务、韦氏记忆量表逻辑记忆、简要视觉记忆测试修订版和韦氏简明智力量表。
强迫症患者作为一个整体，表现为转换能力差，言语和视空间记忆受损。在所有 OCD 患者组中，转换能力受损与强迫症状的严重程度相关，除了 PsT-OCD 患者。只有 PsT-OCD 患者表现出空间识别受损，这与该组患者的转换能力受损相关，而与其他类型的 OCD 患者或健康对照组无关。
我们的研究表明，PsT-OCD 与一种独特的神经认知功能障碍模式相关，因此支持 OCD 的一种不同亚型。
