妊娠期糖尿病或较轻程度的糖耐量异常与子痫前期风险
Gestational diabetes or lesser degrees of glucose intolerance and risk of preeclampsia.
作者信息
Carr Darcy B, Newton Katherine M, Utzschneider Kristina M, Faulenbach Mirjam V, Kahn Steven E, Easterling Thomas R, Heckbert Susan R
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Washington, Seattle, WA 98195, USA.
出版信息
Hypertens Pregnancy. 2011;30(2):153-63. doi: 10.3109/10641950903115012. Epub 2010 Dec 21.
OBJECTIVE
We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia.
METHODS
A retrospective cohort study was performed among 26,105 women.
RESULTS
Preeclampsia was associated with the upper OGCT quartiles [114-132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09-1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21-1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09-1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15-1.83).
CONCLUSION
Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.
目的
我们评估了1小时口服葡萄糖耐量试验（OGCT）和3小时口服葡萄糖耐量试验（OGTT）结果与子痫前期的关联。
方法
对26105名女性进行了一项回顾性队列研究。
结果
与<98mg/dL相比，校正年龄、初孕情况和妊娠期糖尿病后，子痫前期与OGCT四分位数较高者相关[114 - 132mg/dL：比值比（OR）= 1.25，95%置信区间（CI）1.09 - 1.44；>132mg/dL：OR = 1.40，95%CI 1.21 - 1.61]，并且与一个异常的OGTT值（校正后OR 1.38，95%CI 1.09 - 1.75）或妊娠期糖尿病（校正后OR 1.45，95%CI 1.15 - 1.83）相关。
结论
较高的血糖水平与子痫前期相关，提示葡萄糖代谢在病理生理过程中起作用。
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