Department of Ophthalmology, EYE & ENT Hospital of Fudan University, No. 83 Fenyang Road, Shanghai, China.
Curr Eye Res. 2011 Jan;36(1):1-7. doi: 10.3109/02713683.2010.519850.
This study aimed to determine whether patients with dry eye syndrome [DES] have more symptoms of anxiety and depression than controls without DES.
In this case-control study, the sample consisted of 89 DES subjects (13 diagnosed with Sjögren's syndrome [SS]) and 73 control subjects. Each subject was diagnosed as having DES or was chosen as a control subject by an ophthalmologist. The Zung Self Rating Anxiety Scales (SAS), Zung Self Rating Depression Scales (SDS), and Ocular Surface Disease Index (OSDI) were administered to all subjects. Scores of SAS and SDS, measuring level of anxiety and depression symptoms, were compared between the DES group and the control group. Correlations with other health status measures were conducted.
The SAS and SDS scores of the DES group were significantly higher than the control group (P < 0.001, P < 0.001). The prevalence of DES subjects with anxiety or depression symptoms was significantly higher than in the control group (P = 0.003, P < 0.001). In the DES group, SAS scores were found to be correlated with OSDI and educational level. SDS scores were found to be correlated with OSDI. Neither SAS nor SDS scores were correlated with age, sex, household income, tear break up time (BUT), Schirmer Test 1 (S1T), corneal fluorescein staining (FL), or visual acuity.
Anxiety and depression are correlated with DES, demonstrating that DES is an important public health problem that merits increased attention and research.
本研究旨在确定干眼症（DES）患者是否比无 DES 的对照者有更多的焦虑和抑郁症状。
在这项病例对照研究中，样本包括 89 例 DES 患者（13 例诊断为干燥综合征 [SS]）和 73 例对照患者。每位患者均由眼科医生诊断为 DES 或选择为对照者。所有患者均接受了zung 自评焦虑量表（SAS）、zung 自评抑郁量表（SDS）和眼表疾病指数（OSDI）评估。比较 DES 组和对照组的 SAS 和 SDS 评分，评估焦虑和抑郁症状的严重程度。同时进行了与其他健康状况测量指标的相关性分析。
DES 组的 SAS 和 SDS 评分明显高于对照组（P<0.001，P<0.001）。DES 患者中出现焦虑或抑郁症状的比例明显高于对照组（P=0.003，P<0.001）。在 DES 组中，SAS 评分与 OSDI 和教育程度呈正相关，SDS 评分与 OSDI 呈正相关。SAS 和 SDS 评分均与年龄、性别、家庭收入、泪膜破裂时间（BUT）、Schirmer 试验 1（S1T）、角膜荧光素染色（FL）或视力无关。
焦虑和抑郁与 DES 相关，表明 DES 是一个重要的公共卫生问题，值得引起更多关注和研究。
