Department of Neurology, University of PJ Safarik, Tr. SNP 1, Kosice 04001, Slovakia.
Disabil Rehabil. 2011;33(17-18):1587-93. doi: 10.3109/09638288.2010.540292. Epub 2010 Dec 22.
Quality of life (QoL) is an important measure of the burden of disease and could be useful in evaluating patient management and practical interventions. The aim of this study was to explore the association of psychological and clinical variables with QoL in patients with multiple sclerosis (MS).
One hundred and fourteen consecutive patients (mean age 36.1 ± 10.3 years, 72% female) from one MS centre completed the Hospital Anxiety and Depression Scale, the Fatigue Severity Scale and the Short-Form-36 Health Survey (SF-36). Functional disability was assessed using the Expanded Disability Status Scale. Multiple linear regression analyses were performed to analyse demographic, psychological and clinical data.
Functional disability, depression and fatigue were found to be related inversely to the physical health subscale. Disease course, anxiety and depression were associated negatively with the mental health subscale.
Functional disability, depression and fatigue were the main variables related to the perceived physical health subscale, and disease course, anxiety and depression to the perceived mental health subscale in the group of patients with MS. Thus, effective treatment of fatigue, anxiety and depression could be assumed to increase a patient's QoL.
生活质量（QoL）是疾病负担的重要衡量标准，可用于评估患者管理和实际干预措施的效果。本研究旨在探讨心理和临床变量与多发性硬化症（MS）患者生活质量之间的关系。
一家 MS 中心的 114 例连续患者（平均年龄 36.1±10.3 岁，72%为女性）完成了医院焦虑和抑郁量表、疲劳严重程度量表和简明 36 健康调查（SF-36）。使用扩展残疾状况量表评估功能障碍。采用多元线性回归分析对人口统计学、心理和临床数据进行分析。
功能障碍、抑郁和疲劳与身体健康量表呈负相关。病程、焦虑和抑郁与心理健康量表呈负相关。
在 MS 患者组中，功能障碍、抑郁和疲劳是与感知身体健康量表相关的主要变量，而病程、焦虑和抑郁与感知心理健康量表相关。因此，有效治疗疲劳、焦虑和抑郁可以提高患者的生活质量。
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